Survival Comparisons between Early Male and Female Breast Cancer Patients

Kang Wang, Qiu Juan Wang, Yong Fu Xiong, Yang Shi, Wen Jing Yang, Xiang Zhang, Hong Yuan Li

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We aimed to compare the overall survival (OS) and standardized mortality rate (SMR) of the male breast cancer (MBC) with female breast cancer (FBC) after propensity score matching. Based on the Surveillance, Epidemiology, and End Results (SEER), the early breast cancer patients (T1-2N0-2M0) were extracted from 1998-2007. This study included 1,111 and 2,151 patients with early MBC and FBC, respectively, whose clinicopathological characteristics were well balanced. At a mean follow-up time of 97 months, 10-year OS rate was 58.3% in the MBC group and 68.7% in the FBC (log-rank test, P < 0.001; hazard ratio (HR) = 1.45, 95% confidence interval (CI) = 1.29 to 1.64). Adjusted HR for OS between MBC and FBC were revealed from propensity score matched-multivariable Cox proportional hazards models (HR = 1.53, 95% CI = 1.35 to 1.73). Similar adjusted SMRs between MBC and FBC ((SMR = 1.98, 95% CI = 1.83,2.14) for FBC and (SMR = 2.07, 95% CI = 1.88-2.28) for MBC) were observed. The nomogram was constructed for FBC, and predicted probabilities were generally good (C-index = 0.71), whose area under curve is higher than TNM stage classification (0.74 vs 0.62). OS was significantly decreased among early MBC patients compared with FBC, but similar SMRs and its trends by age groups were observed between MBC and FBC except for young patients.

Original languageEnglish (US)
Article number8900
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Male Breast Neoplasms
Breast Neoplasms
Survival
Confidence Intervals
Propensity Score
Mortality
Nomograms
Neoplasm Staging
Proportional Hazards Models

ASJC Scopus subject areas

  • General

Cite this

Wang, K., Wang, Q. J., Xiong, Y. F., Shi, Y., Yang, W. J., Zhang, X., & Li, H. Y. (2018). Survival Comparisons between Early Male and Female Breast Cancer Patients. Scientific Reports, 8(1), [8900]. https://doi.org/10.1038/s41598-018-26199-6

Survival Comparisons between Early Male and Female Breast Cancer Patients. / Wang, Kang; Wang, Qiu Juan; Xiong, Yong Fu; Shi, Yang; Yang, Wen Jing; Zhang, Xiang; Li, Hong Yuan.

In: Scientific Reports, Vol. 8, No. 1, 8900, 01.12.2018.

Research output: Contribution to journalArticle

Wang, Kang ; Wang, Qiu Juan ; Xiong, Yong Fu ; Shi, Yang ; Yang, Wen Jing ; Zhang, Xiang ; Li, Hong Yuan. / Survival Comparisons between Early Male and Female Breast Cancer Patients. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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abstract = "We aimed to compare the overall survival (OS) and standardized mortality rate (SMR) of the male breast cancer (MBC) with female breast cancer (FBC) after propensity score matching. Based on the Surveillance, Epidemiology, and End Results (SEER), the early breast cancer patients (T1-2N0-2M0) were extracted from 1998-2007. This study included 1,111 and 2,151 patients with early MBC and FBC, respectively, whose clinicopathological characteristics were well balanced. At a mean follow-up time of 97 months, 10-year OS rate was 58.3{\%} in the MBC group and 68.7{\%} in the FBC (log-rank test, P < 0.001; hazard ratio (HR) = 1.45, 95{\%} confidence interval (CI) = 1.29 to 1.64). Adjusted HR for OS between MBC and FBC were revealed from propensity score matched-multivariable Cox proportional hazards models (HR = 1.53, 95{\%} CI = 1.35 to 1.73). Similar adjusted SMRs between MBC and FBC ((SMR = 1.98, 95{\%} CI = 1.83,2.14) for FBC and (SMR = 2.07, 95{\%} CI = 1.88-2.28) for MBC) were observed. The nomogram was constructed for FBC, and predicted probabilities were generally good (C-index = 0.71), whose area under curve is higher than TNM stage classification (0.74 vs 0.62). OS was significantly decreased among early MBC patients compared with FBC, but similar SMRs and its trends by age groups were observed between MBC and FBC except for young patients.",
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