Susceptibility to type I diabetes: HLA-DQ and DR revisited

Jin Xiong She

doi:10.1016/0167-5699(96)10014-1

Susceptibility to type I diabetes: HLA-DQ and DR revisited

Jin Xiong She

Research output: Contribution to journal › Comment/debate

302 Scopus citations

Abstract

The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

Original language	English (US)
Pages (from-to)	323-329
Number of pages	7
Journal	Immunology Today
Volume	17
Issue number	7
DOIs	https://doi.org/10.1016/0167-5699(96)10014-1
State	Published - Jul 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology

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She, J. X. (1996). Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunology Today, 17(7), 323-329. https://doi.org/10.1016/0167-5699(96)10014-1

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