Susceptibility to type I diabetes: HLA-DQ and DR revisited

Jin-Xiong She

Research output: Contribution to journal › Comment/debate

298 Citations (Scopus)

Abstract

The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalImmunology Today
Volume17
Issue number7
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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HLA-DQ Antigens
HLA-DR Antigens
Type 1 Diabetes Mellitus
Linkage Disequilibrium

ASJC Scopus subject areas

  • Immunology

Cite this

Susceptibility to type I diabetes : HLA-DQ and DR revisited. / She, Jin-Xiong.

In: Immunology Today, Vol. 17, No. 7, 01.01.1996, p. 323-329.

Research output: Contribution to journal › Comment/debate

She, J-X 1996, 'Susceptibility to type I diabetes: HLA-DQ and DR revisited', Immunology Today, vol. 17, no. 7, pp. 323-329. https://doi.org/10.1016/0167-5699(96)10014-1
She J-X. Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunology Today. 1996 Jan 1;17(7):323-329. https://doi.org/10.1016/0167-5699(96)10014-1
She, Jin-Xiong. / Susceptibility to type I diabetes : HLA-DQ and DR revisited. In: Immunology Today. 1996 ; Vol. 17, No. 7. pp. 323-329.
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