Susceptibility to type I diabetes: HLA-DQ and DR revisited

Jin Xiong She

doi:10.1016/0167-5699(96)10014-1

Susceptibility to type I diabetes: HLA-DQ and DR revisited

Jin Xiong She

Research output: Contribution to journal › Comment/debate › peer-review

303 Scopus citations

Abstract

The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

Original language	English (US)
Pages (from-to)	323-329
Number of pages	7
Journal	Immunology Today
Volume	17
Issue number	7
DOIs	https://doi.org/10.1016/0167-5699(96)10014-1
State	Published - Jul 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology

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Cite this

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title = "Susceptibility to type I diabetes: HLA-DQ and DR revisited",

abstract = "The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.",

author = "She, {Jin Xiong}",

note = "Funding Information: This work was supported by the Juvenile Diabetes Foundation (grants JDF193182 and JDF195094)a nd the National Institutes of Health (grant HL47138). I thank V. Ramiya, A. Muir, N.K. Maclaren, M. Yui, B. Winter, G. Thomson,J . C.urnelius,H .S. Huang and D. Schatz for their valuables ug-gestionso n the manuscripta nd/or for providing patients amples.I am alho grateful to a11m y students and technicala ssistants,p articularly J.T. Peng, J.Y. She, L.P. Zhang, D.F. Luo and M.M. Bui.",

year = "1996",

month = jul,

doi = "10.1016/0167-5699(96)10014-1",

language = "English (US)",

volume = "17",

pages = "323--329",

journal = "Trends in Immunology",

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T2 - HLA-DQ and DR revisited

AU - She, Jin Xiong

N1 - Funding Information: This work was supported by the Juvenile Diabetes Foundation (grants JDF193182 and JDF195094)a nd the National Institutes of Health (grant HL47138). I thank V. Ramiya, A. Muir, N.K. Maclaren, M. Yui, B. Winter, G. Thomson,J . C.urnelius,H .S. Huang and D. Schatz for their valuables ug-gestionso n the manuscripta nd/or for providing patients amples.I am alho grateful to a11m y students and technicala ssistants,p articularly J.T. Peng, J.Y. She, L.P. Zhang, D.F. Luo and M.M. Bui.

PY - 1996/7

Y1 - 1996/7

N2 - The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

AB - The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

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JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

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Susceptibility to type I diabetes: HLA-DQ and DR revisited

Abstract

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