TY - JOUR
T1 - Susceptibility to type I diabetes
T2 - HLA-DQ and DR revisited
AU - She, Jin Xiong
PY - 1996/7
Y1 - 1996/7
N2 - The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.
AB - The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.
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U2 - 10.1016/0167-5699(96)10014-1
DO - 10.1016/0167-5699(96)10014-1
M3 - Comment/debate
C2 - 8763818
AN - SCOPUS:0029905302
VL - 17
SP - 323
EP - 329
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 7
ER -