TY - JOUR
T1 - Synergistic effects of INTERCEED(TC7) and heparin in reducing adhesion formation in the rabbit uterine horn model
AU - Diamond, M. P.
AU - Linsky, C. B.
AU - Cunningham, T.
AU - Kamp, L.
AU - Pines, E.
AU - DeCherney, A. H.
AU - DiZerega, G. S.
N1 - Funding Information:
Received March 15, 1990; revised and accepted August 16, 1990. * Johnson and Johnson Medical, Inc., New Brunswick, New Jersey. t Presented in part at the 43rd Annual Meeting of The American Fertility Society, Reno, Nevada, September 28 to 30, 1987; and at the 73rd Annual Meeting of The American College of Surgeons, San Francisco, California, October 11 to 16,1987. :j: Supported by Johnson and Johnson Medical, Inc., New Brunswick, New Jersey. § Department of Obstetrics and Gynecology, Yale University School of Medicine. II Recipient of the Clinical Associate Physician Award of the Yale General Clinical Research Center of the National Institutes of Health, Bethesda, Maryland. \[ Reprint requests: Michael P. Diamond, M.D., Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, P. O. Box 3333, New Haven, Connecticut 06510. # Johnson and Johnson Medical, Inc., New Brunswick, New Jersey. ** Department of Obstetrics and Gynecology, University of Southern California Medical Center.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - Surgical adjuvants are commonly employed to reduce the frequency of postoperative adhesion development after reproductive pelvic surgery. The ability of indomethacin, promethazine, dexamethasone, Intralipid, progesterone, and heparin to reduce adhesion formation in combination with INTERCEED(TC7) (Johnson and Johnson Medical, Inc., New Brunswick, NJ), an absorbable barrier that alone reduces adhesion formation, was examined in a rabbit uterine horn model. A significant reduction in adhesion formation was only observed with the combination of INTERCEED(TC7) plus heparin. In additional studies, heparin delivery by intraperitoneal (IP) lavage, intravenous injection, or intra-abdominal instillation failed to demonstrate efficacy. Similarly, heparin delivery with other barriers or IP instillates (carboxymethylcellulose or 32% Dextran 70) failed to reduce adhesion formation. We conclude that INTERCEED(TC7) can be efficaciously utilized as a carrier to deliver heparin to traumatized surfaces, thereby reducing adhesion formation.
AB - Surgical adjuvants are commonly employed to reduce the frequency of postoperative adhesion development after reproductive pelvic surgery. The ability of indomethacin, promethazine, dexamethasone, Intralipid, progesterone, and heparin to reduce adhesion formation in combination with INTERCEED(TC7) (Johnson and Johnson Medical, Inc., New Brunswick, NJ), an absorbable barrier that alone reduces adhesion formation, was examined in a rabbit uterine horn model. A significant reduction in adhesion formation was only observed with the combination of INTERCEED(TC7) plus heparin. In additional studies, heparin delivery by intraperitoneal (IP) lavage, intravenous injection, or intra-abdominal instillation failed to demonstrate efficacy. Similarly, heparin delivery with other barriers or IP instillates (carboxymethylcellulose or 32% Dextran 70) failed to reduce adhesion formation. We conclude that INTERCEED(TC7) can be efficaciously utilized as a carrier to deliver heparin to traumatized surfaces, thereby reducing adhesion formation.
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U2 - 10.1016/s0015-0282(16)54134-x
DO - 10.1016/s0015-0282(16)54134-x
M3 - Article
C2 - 1991536
AN - SCOPUS:0026092521
VL - 55
SP - 389
EP - 394
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -