Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

T D Venu; S A Khanum; Aiysha Firdouse; B K Manuprasad; Sheena Shashikanth; Riyaz Mohamed; Bannikuppe Sannanaik Vishwanth

doi:10.1016/j.bmcl.2008.06.061

Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

T D Venu, S A Khanum, Aiysha Firdouse, B K Manuprasad, Sheena Shashikanth, Riyaz Mohamed, Bannikuppe Sannanaik Vishwanth

Physiology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

Original language	English (US)
Pages (from-to)	4409-12
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2008.06.061
State	Published - Aug 1 2008

Keywords

Algorithms
Animals
Animals, Inbred Strains
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis
Disease Models, Animal
Edema/chemically induced
Foot/pathology
Mice
Phospholipases A2/metabolism
Prostaglandin-Endoperoxide Synthases/metabolism
Pyrimidines/chemical synthesis
Rats
Ulcer/etiology

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10.1016/j.bmcl.2008.06.061

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title = "Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines",

abstract = "Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.",

keywords = "Algorithms, Animals, Animals, Inbred Strains, Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis, Disease Models, Animal, Edema/chemically induced, Foot/pathology, Mice, Phospholipases A2/metabolism, Prostaglandin-Endoperoxide Synthases/metabolism, Pyrimidines/chemical synthesis, Rats, Ulcer/etiology",

author = "Venu, {T D} and Khanum, {S A} and Aiysha Firdouse and Manuprasad, {B K} and Sheena Shashikanth and Riyaz Mohamed and Vishwanth, {Bannikuppe Sannanaik}",

year = "2008",

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day = "1",

doi = "10.1016/j.bmcl.2008.06.061",

language = "English (US)",

volume = "18",

pages = "4409--12",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "15",

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TY - JOUR

T1 - Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

AU - Venu, T D

AU - Khanum, S A

AU - Firdouse, Aiysha

AU - Manuprasad, B K

AU - Shashikanth, Sheena

AU - Mohamed, Riyaz

AU - Vishwanth, Bannikuppe Sannanaik

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

AB - Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

KW - Algorithms

KW - Animals

KW - Animals, Inbred Strains

KW - Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis

KW - Disease Models, Animal

KW - Edema/chemically induced

KW - Foot/pathology

KW - Mice

KW - Phospholipases A2/metabolism

KW - Prostaglandin-Endoperoxide Synthases/metabolism

KW - Pyrimidines/chemical synthesis

KW - Rats

KW - Ulcer/etiology

U2 - 10.1016/j.bmcl.2008.06.061

DO - 10.1016/j.bmcl.2008.06.061

M3 - Article

C2 - 18621525

SN - 0960-894X

VL - 18

SP - 4409

EP - 4412

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

Abstract

Keywords

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