Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

T D Venu, S A Khanum, Aiysha Firdouse, B K Manuprasad, Sheena Shashikanth, Riyaz Mohamed, Bannikuppe Sannanaik Vishwanth

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

Original languageEnglish (US)
Pages (from-to)4409-12
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number15
DOIs
StatePublished - Aug 1 2008

Keywords

  • Algorithms
  • Animals
  • Animals, Inbred Strains
  • Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis
  • Disease Models, Animal
  • Edema/chemically induced
  • Foot/pathology
  • Mice
  • Phospholipases A2/metabolism
  • Prostaglandin-Endoperoxide Synthases/metabolism
  • Pyrimidines/chemical synthesis
  • Rats
  • Ulcer/etiology

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