Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Novel, mesalazine, metronidazole conjugates 6a-e with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates exhibit comparable anti-inflammatory activity with parent drugs and (b) the potent bis-conjugates show no visible stomach lesions. 3D-pharmacophore and 2D-QSAR modeling support the observed bio-properties.

Original languageEnglish (US)
Pages (from-to)2314-20
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number11
DOIs
StatePublished - Jun 1 2015

Keywords

  • Animals
  • Anti-Inflammatory Agents
  • Indomethacin
  • Mesalamine
  • Metronidazole
  • Mice
  • Molecular Structure
  • Quantitative Structure-Activity Relationship
  • Stomach Ulcer
  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates'. Together they form a unique fingerprint.

  • Cite this