Novel, mesalazine, metronidazole conjugates 6a-e with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates exhibit comparable anti-inflammatory activity with parent drugs and (b) the potent bis-conjugates show no visible stomach lesions. 3D-pharmacophore and 2D-QSAR modeling support the observed bio-properties.
- Anti-Inflammatory Agents
- Molecular Structure
- Quantitative Structure-Activity Relationship
- Stomach Ulcer
- Journal Article
- Research Support, Non-U.S. Gov't