Systemic lupus erythematosus in pregnancy

Lawrence D Devoe, Roger L. Taylor

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Most literature on pregnancies in patients with systemic lupus erythematosus (SLE) is retrospective and selective. This report is a detailed, prospective analysis of 13 pregnancies in eight women with SLE. Pregnancy was best tolerated by mothers without significant nephropathy or cardiopathy who had been in clinical remission for more than three months prior to conception. Management was aided by serial evaluation of complement (C3 and C4) levels and careful supervision of immunosuppressive therapy when indicated. Although fetal status was closely monitored, premature deliveries and spontaneous abortions occurred frequently. No malformations or adverse sequelae were noted in surviving infants exposed to immunosuppressive agents during gestation.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume135
Issue number4
DOIs
StatePublished - Oct 15 1979

Fingerprint

Systemic Lupus Erythematosus
Pregnancy
Immunosuppressive Agents
Complement C4
Complement C3
Spontaneous Abortion
Mothers
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Systemic lupus erythematosus in pregnancy. / Devoe, Lawrence D; Taylor, Roger L.

In: American Journal of Obstetrics and Gynecology, Vol. 135, No. 4, 15.10.1979, p. 473-479.

Research output: Contribution to journalArticle

@article{bbdb1a4e21a1452e816eadb5d13e0f5f,
title = "Systemic lupus erythematosus in pregnancy",
abstract = "Most literature on pregnancies in patients with systemic lupus erythematosus (SLE) is retrospective and selective. This report is a detailed, prospective analysis of 13 pregnancies in eight women with SLE. Pregnancy was best tolerated by mothers without significant nephropathy or cardiopathy who had been in clinical remission for more than three months prior to conception. Management was aided by serial evaluation of complement (C3 and C4) levels and careful supervision of immunosuppressive therapy when indicated. Although fetal status was closely monitored, premature deliveries and spontaneous abortions occurred frequently. No malformations or adverse sequelae were noted in surviving infants exposed to immunosuppressive agents during gestation.",
author = "Devoe, {Lawrence D} and Taylor, {Roger L.}",
year = "1979",
month = "10",
day = "15",
doi = "10.1016/0002-9378(79)90434-4",
language = "English (US)",
volume = "135",
pages = "473--479",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Systemic lupus erythematosus in pregnancy

AU - Devoe, Lawrence D

AU - Taylor, Roger L.

PY - 1979/10/15

Y1 - 1979/10/15

N2 - Most literature on pregnancies in patients with systemic lupus erythematosus (SLE) is retrospective and selective. This report is a detailed, prospective analysis of 13 pregnancies in eight women with SLE. Pregnancy was best tolerated by mothers without significant nephropathy or cardiopathy who had been in clinical remission for more than three months prior to conception. Management was aided by serial evaluation of complement (C3 and C4) levels and careful supervision of immunosuppressive therapy when indicated. Although fetal status was closely monitored, premature deliveries and spontaneous abortions occurred frequently. No malformations or adverse sequelae were noted in surviving infants exposed to immunosuppressive agents during gestation.

AB - Most literature on pregnancies in patients with systemic lupus erythematosus (SLE) is retrospective and selective. This report is a detailed, prospective analysis of 13 pregnancies in eight women with SLE. Pregnancy was best tolerated by mothers without significant nephropathy or cardiopathy who had been in clinical remission for more than three months prior to conception. Management was aided by serial evaluation of complement (C3 and C4) levels and careful supervision of immunosuppressive therapy when indicated. Although fetal status was closely monitored, premature deliveries and spontaneous abortions occurred frequently. No malformations or adverse sequelae were noted in surviving infants exposed to immunosuppressive agents during gestation.

UR - http://www.scopus.com/inward/record.url?scp=0018305340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018305340&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(79)90434-4

DO - 10.1016/0002-9378(79)90434-4

M3 - Article

VL - 135

SP - 473

EP - 479

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 4

ER -