Systemic lupus erythematosus in pregnancy

Lawrence D. Devoe, Roger L. Taylor

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Most literature on pregnancies in patients with systemic lupus erythematosus (SLE) is retrospective and selective. This report is a detailed, prospective analysis of 13 pregnancies in eight women with SLE. Pregnancy was best tolerated by mothers without significant nephropathy or cardiopathy who had been in clinical remission for more than three months prior to conception. Management was aided by serial evaluation of complement (C3 and C4) levels and careful supervision of immunosuppressive therapy when indicated. Although fetal status was closely monitored, premature deliveries and spontaneous abortions occurred frequently. No malformations or adverse sequelae were noted in surviving infants exposed to immunosuppressive agents during gestation.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume135
Issue number4
DOIs
StatePublished - Oct 15 1979
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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