T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II

R. T. McCarthy; C. Isales; H. Rasmussen

doi:10.1073/pnas.90.8.3260

T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II

R. T. McCarthy, C. Isales, H. Rasmussen

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Abstract

With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell- attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.

Original language	English (US)
Pages (from-to)	3260-3264
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	90
Issue number	8
DOIs	https://doi.org/10.1073/pnas.90.8.3260
State	Published - 1993
Externally published	Yes

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AB - With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell- attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.

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T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II

Abstract

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