Abstract
With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell- attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3260-3264 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 90 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1 1993 |
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Cite this
T-type calcium channels in adrenal glomerulosa cells : GTP-dependent modulation by angiotensin II. / McCarthy, R. T.; Isales, Carlos M; Rasmussen, H.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 8, 01.01.1993, p. 3260-3264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T-type calcium channels in adrenal glomerulosa cells
T2 - GTP-dependent modulation by angiotensin II
AU - McCarthy, R. T.
AU - Isales, Carlos M
AU - Rasmussen, H.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell- attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
AB - With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell- attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
UR - http://www.scopus.com/inward/record.url?scp=0027520890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027520890&partnerID=8YFLogxK
U2 - 10.1073/pnas.90.8.3260
DO - 10.1073/pnas.90.8.3260
M3 - Article
C2 - 8386369
AN - SCOPUS:0027520890
VL - 90
SP - 3260
EP - 3264
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 8
ER -