Abstract
With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell- attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3260-3264 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 90 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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McCarthy, R. T., Isales, C., & Rasmussen, H. (1993). T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II. Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3260-3264. https://doi.org/10.1073/pnas.90.8.3260