Tamm-Horsfall autoantibodies in interstitial cystitis

Durwood Earnest Neal, J. P. Dilworth, M. B. Kaack

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Interstitial cystitis presents a diagnostic and therapeutic challenge. Although many etiologies, including autoimmunity, have been proposed its pathogenesis remains obscure. Tamm-Horsfall protein has been identified in the superficial urothelium of patients with interstitial cystitis demonstrating abnormal urothelial permeability. Eight patients with a clinical diagnosis of interstitial cystitis underwent cystoscopy and bladder biopsy. Characteristic cystoscopic findings were present, and each patient had chronic inflammation and mast cells by histopathological analysis. Preoperative anti-Tamm-Horsfall protein serum antibody (IgG) titers were determined by enzyme-linked immunosorbent assay (range 500 to 8,000, mean 2,750). A control group of 8 patients with a negative urological history also had titers of 0 to 500 (p = 0.02). The humoral response to Tamm-Horsfall protein in these patients suggests a role for Tamm-Horsfall protein in interstitial cystitis. Measurement of serum Tamm-Horsfall protein antibody may prove to be useful as a noninvasive diagnostic test in patients with this disease.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalJournal of Urology
Volume145
Issue number1
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Interstitial Cystitis
Uromodulin
Autoantibodies
Urothelium
Cystoscopy
Antibodies
Autoimmunity
Routine Diagnostic Tests
Mast Cells
Blood Proteins
Permeability
Urinary Bladder
Immunoglobulin G
History
Enzyme-Linked Immunosorbent Assay
Inflammation
Biopsy
Control Groups
Serum

Keywords

  • bladder, cystitis, autoantibodies

ASJC Scopus subject areas

  • Urology

Cite this

Tamm-Horsfall autoantibodies in interstitial cystitis. / Neal, Durwood Earnest; Dilworth, J. P.; Kaack, M. B.

In: Journal of Urology, Vol. 145, No. 1, 01.01.1991, p. 37-39.

Research output: Contribution to journalArticle

Neal, Durwood Earnest ; Dilworth, J. P. ; Kaack, M. B. / Tamm-Horsfall autoantibodies in interstitial cystitis. In: Journal of Urology. 1991 ; Vol. 145, No. 1. pp. 37-39.
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