Targets for vascular protection after acute ischemic stroke

Susan C. Fagan, David C. Hess, Elizabeth J. Hohnadel, David M. Pollock, Adviye Ergul

Research output: Contribution to journalReview article

202 Citations (Scopus)

Abstract

Background-Vascular damage caused by cerebral ischemia leads to edema, hemorrhage formation, and worsened outcomes in ischemic stroke patients. Therapeutic interventions need to be developed to provide vascular protection. The purpose of this review is to identify the pathophysiologic processes involved in vascular damage after ischemia, which may lead to strategies to provide vascular protection in ischemic stroke patients. Summary of Comment-The pathologic processes caused by vascular injury after an occlusion of a cerebral artery can be separated into acute (hours), subacute (hours to days), and chronic (days to months). Targets for intervention can be identified for all 3 stages. Acutely, superoxide is the predominant mediator, followed by inflammatory mediators and proteases subacutely. In the chronic phase, proapoptotic gene products have been implicated. Conclusions-Pharmacological agents designed to target specific pathologic and protective processes affecting the vasculature should be used in clinical trials of vascular protection after acute ischemic stroke.

Original languageEnglish (US)
Pages (from-to)2220-2225
Number of pages6
JournalStroke
Volume35
Issue number9
DOIs
StatePublished - Sep 1 2004

Fingerprint

Blood Vessels
Stroke
Pathologic Processes
Cerebral Arteries
Vascular System Injuries
Brain Ischemia
Superoxides
Edema
Peptide Hydrolases
Ischemia
Clinical Trials
Pharmacology
Hemorrhage
Genes
Therapeutics

Keywords

  • Cerebral ischemia, focal
  • Clinical trials
  • Free radicals
  • Ischemia
  • Pharmacology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Fagan, S. C., Hess, D. C., Hohnadel, E. J., Pollock, D. M., & Ergul, A. (2004). Targets for vascular protection after acute ischemic stroke. Stroke, 35(9), 2220-2225. https://doi.org/10.1161/01.STR.0000138023.60272.9e

Targets for vascular protection after acute ischemic stroke. / Fagan, Susan C.; Hess, David C.; Hohnadel, Elizabeth J.; Pollock, David M.; Ergul, Adviye.

In: Stroke, Vol. 35, No. 9, 01.09.2004, p. 2220-2225.

Research output: Contribution to journalReview article

Fagan, SC, Hess, DC, Hohnadel, EJ, Pollock, DM & Ergul, A 2004, 'Targets for vascular protection after acute ischemic stroke', Stroke, vol. 35, no. 9, pp. 2220-2225. https://doi.org/10.1161/01.STR.0000138023.60272.9e
Fagan, Susan C. ; Hess, David C. ; Hohnadel, Elizabeth J. ; Pollock, David M. ; Ergul, Adviye. / Targets for vascular protection after acute ischemic stroke. In: Stroke. 2004 ; Vol. 35, No. 9. pp. 2220-2225.
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