Technology Transfer From Biomedical Research to Clinical Practice

Measuring Innovation Performance

E Andrew Balas, Peter L. Elkin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Studies documented 17 years of transfer time from clinical trials to practice of care. Launched in 2002, the National Institutes of Health (NIH) translational research initiative needs to develop metrics for impact assessment. A recent White House report highlighted that research and development productivity is declining as a result of increased research spending while the new drugs output is flat. The goal of this study was to develop an expanded model of research-based innovation and performance thresholds of transfer from research to practice. Models for transfer of research to practice have been collected and reviewed. Subsequently, innovation pathways have been specified based on common characteristics. An integrated, intellectual property transfer model is described. The central but often disregarded role of research innovation disclosure is highlighted. Measures of research transfer and milestones of progress have been identified based on the Association of University Technology Managers 2012 performance reports. Numeric milestones of technology transfer are recommended at threshold (top 50%), target (top 25%), and stretch goal (top 10%) performance levels. Transfer measures and corresponding target levels include research spending to disclosure (<$1.88 million), disclosure to patents (>0.81), patents to start-up (>0.1), patents to licenses (>2.25), and average per license income (>$48,000). Several limitations of measurement are described. Academic institutions should take strategic steps to bring innovation to the center of scholarly discussions. Research on research, particularly on pathways to disclosures, is needed to improve R&D productivity. Researchers should be informed about the technology transfer performance of their institution and regulations should better support innovators.

Original languageEnglish (US)
Pages (from-to)505-517
Number of pages13
JournalEvaluation and the Health Professions
Volume36
Issue number4
DOIs
StatePublished - Dec 1 2013

Fingerprint

Technology Transfer
Biomedical Research
Research
Disclosure
Patents
Licensure
Intellectual Property
Translational Medical Research
National Institutes of Health (U.S.)
Research Personnel
Clinical Trials
Technology

Keywords

  • CTSA
  • biomedical innovation
  • performance improvement
  • quality measures
  • technology transfer
  • translational research

ASJC Scopus subject areas

  • Health Policy

Cite this

Technology Transfer From Biomedical Research to Clinical Practice : Measuring Innovation Performance. / Balas, E Andrew; Elkin, Peter L.

In: Evaluation and the Health Professions, Vol. 36, No. 4, 01.12.2013, p. 505-517.

Research output: Contribution to journalArticle

@article{0f27c3f3e1ae4ac89954507fdbf0ebba,
title = "Technology Transfer From Biomedical Research to Clinical Practice: Measuring Innovation Performance",
abstract = "Studies documented 17 years of transfer time from clinical trials to practice of care. Launched in 2002, the National Institutes of Health (NIH) translational research initiative needs to develop metrics for impact assessment. A recent White House report highlighted that research and development productivity is declining as a result of increased research spending while the new drugs output is flat. The goal of this study was to develop an expanded model of research-based innovation and performance thresholds of transfer from research to practice. Models for transfer of research to practice have been collected and reviewed. Subsequently, innovation pathways have been specified based on common characteristics. An integrated, intellectual property transfer model is described. The central but often disregarded role of research innovation disclosure is highlighted. Measures of research transfer and milestones of progress have been identified based on the Association of University Technology Managers 2012 performance reports. Numeric milestones of technology transfer are recommended at threshold (top 50{\%}), target (top 25{\%}), and stretch goal (top 10{\%}) performance levels. Transfer measures and corresponding target levels include research spending to disclosure (<$1.88 million), disclosure to patents (>0.81), patents to start-up (>0.1), patents to licenses (>2.25), and average per license income (>$48,000). Several limitations of measurement are described. Academic institutions should take strategic steps to bring innovation to the center of scholarly discussions. Research on research, particularly on pathways to disclosures, is needed to improve R&D productivity. Researchers should be informed about the technology transfer performance of their institution and regulations should better support innovators.",
keywords = "CTSA, biomedical innovation, performance improvement, quality measures, technology transfer, translational research",
author = "Balas, {E Andrew} and Elkin, {Peter L.}",
year = "2013",
month = "12",
day = "1",
doi = "10.1177/0163278713508135",
language = "English (US)",
volume = "36",
pages = "505--517",
journal = "Evaluation and the Health Professions",
issn = "0163-2787",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Technology Transfer From Biomedical Research to Clinical Practice

T2 - Measuring Innovation Performance

AU - Balas, E Andrew

AU - Elkin, Peter L.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Studies documented 17 years of transfer time from clinical trials to practice of care. Launched in 2002, the National Institutes of Health (NIH) translational research initiative needs to develop metrics for impact assessment. A recent White House report highlighted that research and development productivity is declining as a result of increased research spending while the new drugs output is flat. The goal of this study was to develop an expanded model of research-based innovation and performance thresholds of transfer from research to practice. Models for transfer of research to practice have been collected and reviewed. Subsequently, innovation pathways have been specified based on common characteristics. An integrated, intellectual property transfer model is described. The central but often disregarded role of research innovation disclosure is highlighted. Measures of research transfer and milestones of progress have been identified based on the Association of University Technology Managers 2012 performance reports. Numeric milestones of technology transfer are recommended at threshold (top 50%), target (top 25%), and stretch goal (top 10%) performance levels. Transfer measures and corresponding target levels include research spending to disclosure (<$1.88 million), disclosure to patents (>0.81), patents to start-up (>0.1), patents to licenses (>2.25), and average per license income (>$48,000). Several limitations of measurement are described. Academic institutions should take strategic steps to bring innovation to the center of scholarly discussions. Research on research, particularly on pathways to disclosures, is needed to improve R&D productivity. Researchers should be informed about the technology transfer performance of their institution and regulations should better support innovators.

AB - Studies documented 17 years of transfer time from clinical trials to practice of care. Launched in 2002, the National Institutes of Health (NIH) translational research initiative needs to develop metrics for impact assessment. A recent White House report highlighted that research and development productivity is declining as a result of increased research spending while the new drugs output is flat. The goal of this study was to develop an expanded model of research-based innovation and performance thresholds of transfer from research to practice. Models for transfer of research to practice have been collected and reviewed. Subsequently, innovation pathways have been specified based on common characteristics. An integrated, intellectual property transfer model is described. The central but often disregarded role of research innovation disclosure is highlighted. Measures of research transfer and milestones of progress have been identified based on the Association of University Technology Managers 2012 performance reports. Numeric milestones of technology transfer are recommended at threshold (top 50%), target (top 25%), and stretch goal (top 10%) performance levels. Transfer measures and corresponding target levels include research spending to disclosure (<$1.88 million), disclosure to patents (>0.81), patents to start-up (>0.1), patents to licenses (>2.25), and average per license income (>$48,000). Several limitations of measurement are described. Academic institutions should take strategic steps to bring innovation to the center of scholarly discussions. Research on research, particularly on pathways to disclosures, is needed to improve R&D productivity. Researchers should be informed about the technology transfer performance of their institution and regulations should better support innovators.

KW - CTSA

KW - biomedical innovation

KW - performance improvement

KW - quality measures

KW - technology transfer

KW - translational research

UR - http://www.scopus.com/inward/record.url?scp=84887432778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887432778&partnerID=8YFLogxK

U2 - 10.1177/0163278713508135

DO - 10.1177/0163278713508135

M3 - Article

VL - 36

SP - 505

EP - 517

JO - Evaluation and the Health Professions

JF - Evaluation and the Health Professions

SN - 0163-2787

IS - 4

ER -