The 5XFAD mouse model of Alzheimer's disease exhibits an age-dependent increase in anti-ceramide IgG and exogenous administration of ceramide further increases anti-ceramide titers and amyloid plaque burden

Michael B. Dinkins, Somsankar Dasgupta, Guanghu Wang, Gu Zhu, Qian He, Ji Na Kong, Erhard Bieberich

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We present evidence that 5XFAD Alzheimer's disease model mice develop an age-dependent increase in antibodies against ceramide, suggesting involvement of autoimmunity against ceramide in Alzheimer's disease pathology. To test this, we increased serum anti-ceramide IgG (2-fold) by ceramide administration and analyzed amyloid plaque formation in 5XFAD mice. There were no differences in soluble or total amyloid-β levels. However, females receiving ceramide had increased plaque burden (number, area, and size) compared to controls. Ceramide-treated mice showed an increase of serum exosomes (up to 3-fold using Alix as marker), suggesting that systemic anti-ceramide IgG and exosome levels are correlated with enhanced plaque formation.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalJournal of Alzheimer's Disease
Volume46
Issue number1
DOIs
StatePublished - May 7 2015

Keywords

  • Alzheimer's disease
  • amyloid
  • antibodies
  • ceramide
  • exosomes
  • mice

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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