The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus

W. Almaguer-Melian, L. Martínez-Martí, J. U. Frey, J. A. Bergado

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Long-term potentiation (LTP) in the dentate gyrus can be modulated and prolonged by emotional/motivational influences when concurrently activated. A similar effect on LTP can be obtained by stimulating the amygdala, suggesting that this limbic structure might be part of the neural system involved in behavioural reinforcement. To confirm this we have performed a series of experiments in which the basolateral amygdala was either temporary inactivated by injection of lidocaine or permanently lesioned electrolytically. Both manipulations completely blocked the reinforcing effect of a motivational stimulus (drinking after 24-h deprivation) on LTP at the perforant pathway-dentate gyrus synapses, whilst leaving intact the non-reinforced potentiation. These results demonstrate that the basolateral amygdala is a key structure within the system involved in the modulatory interaction between the affective status of the animal and the mechanisms of functional plasticity.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalNeuroscience
Volume119
Issue number2
DOIs
StatePublished - Jun 27 2003

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Long-Term Potentiation
Amygdala
Hippocampus
Dentate Gyrus
Perforant Pathway
Lidocaine
Synapses
Drinking
Injections
Basolateral Nuclear Complex

Keywords

  • Electrolytic lesions
  • Emotion
  • Lidocaine
  • Memory
  • Motivation
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus. / Almaguer-Melian, W.; Martínez-Martí, L.; Frey, J. U.; Bergado, J. A.

In: Neuroscience, Vol. 119, No. 2, 27.06.2003, p. 319-322.

Research output: Contribution to journalArticle

Almaguer-Melian, W. ; Martínez-Martí, L. ; Frey, J. U. ; Bergado, J. A. / The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus. In: Neuroscience. 2003 ; Vol. 119, No. 2. pp. 319-322.
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