The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma

Alyson Haslam, Sara Wagner Robb, James R. Hébert, Hanwen Huang, Michael D. Wirth, Nitin Shivappa, Mark H. Ebell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. Design Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models. Setting Ten cancer screening centres across the USA. Subjects Participants were those included in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Results Among the 44 278 individuals included in these analyses, men with diets in the most inflammatory quartile of DII scores had higher odds of all types of CRA (advanced, non-advanced and multiple (>1)) compared with those with diets in the least inflammatory quartile of DII scores. In fully adjusted models, compared with those with DII scores in quartile 1 (least inflammatory), males with DII scores in quartile 3 (adjusted odds ratio (aOR)=1·28; 95 % CI 1·12, 1·47) and quartile 4 (aOR=1·41; 95 % CI 1·23, 1·62) were more likely to have prevalent distal CRA. Higher DII scores, representing a more inflammatory diet, also were weakly associated with a higher prevalence of CRA in women. Conclusions Implementing an anti-inflammatory diet may be an effective means of primary prevention of CRA, especially in men.

Original languageEnglish (US)
Pages (from-to)1609-1616
Number of pages8
JournalPublic Health Nutrition
Volume20
Issue number9
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Adenoma
Diet
Early Detection of Cancer
Logistic Models
Odds Ratio
Primary Prevention
Ovarian Neoplasms
Colorectal Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Anti-Inflammatory Agents
Cross-Sectional Studies
Neoplasms

Keywords

  • Colorectal adenoma
  • Dietary Inflammatory Index
  • Racial disparities

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Haslam, A., Wagner Robb, S., Hébert, J. R., Huang, H., Wirth, M. D., Shivappa, N., & Ebell, M. H. (2017). The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma. Public Health Nutrition, 20(9), 1609-1616. https://doi.org/10.1017/S1368980017000453

The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma. / Haslam, Alyson; Wagner Robb, Sara; Hébert, James R.; Huang, Hanwen; Wirth, Michael D.; Shivappa, Nitin; Ebell, Mark H.

In: Public Health Nutrition, Vol. 20, No. 9, 01.06.2017, p. 1609-1616.

Research output: Contribution to journalArticle

Haslam, A, Wagner Robb, S, Hébert, JR, Huang, H, Wirth, MD, Shivappa, N & Ebell, MH 2017, 'The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma', Public Health Nutrition, vol. 20, no. 9, pp. 1609-1616. https://doi.org/10.1017/S1368980017000453
Haslam, Alyson ; Wagner Robb, Sara ; Hébert, James R. ; Huang, Hanwen ; Wirth, Michael D. ; Shivappa, Nitin ; Ebell, Mark H. / The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma. In: Public Health Nutrition. 2017 ; Vol. 20, No. 9. pp. 1609-1616.
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