The association between laryngeal pseudosulcus and laryngopharyngeal reflux

Peter C. Belafsky, Gregory N Postma, James A. Koufman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

BACKGROUND: A pattern of edema on the ventral surface of the vocal fold, called pseudosulcus vocalis, was described in 1995. It refers to infraglottic edema extending from the anterior commissure to the posterior larynx. It can be differentiated from sulcus vergeture, which is caused by adhesion of the vocal fold epithelium to the vocal ligament. Although it has been related to laryngopharyngeal reflux (LPR), this has not been thoroughly investigated. PURPOSE: Our goal was to evaluate the association between pseudosulcus and LPR. METHODS: Thirty patients with a clinical diagnosis of LPR confirmed by double-probe pH monitoring and 30 controls without LPR were enrolled. The prevalence of pseudosulcus was determined with fiber-optic laryngoscopy. RESULTS: Seventy percent (21 of 30) of patients with LPR and 30% (9 of 30) of controls had pseudosulcus. Patients with pseudosulcus were 2.3 times more likely to have pH-documented LPR (95% confidence interval 1.3-4.2). The sensitivity and specificity of pseudosulcus in the diagnosis of LPR are 70% and 77%, respectively. CONCLUSIONS: Pseudosulcus is highly correlated with pH-documented LPR (P < 0.001). The presence of pseudosulcus is suggestive of LPR.

Original languageEnglish (US)
Pages (from-to)649-652
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Volume126
Issue number6
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Laryngopharyngeal Reflux
Vocal Cords
Edema
Laryngoscopy
Larynx
Epithelium
Confidence Intervals

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

The association between laryngeal pseudosulcus and laryngopharyngeal reflux. / Belafsky, Peter C.; Postma, Gregory N; Koufman, James A.

In: Otolaryngology - Head and Neck Surgery, Vol. 126, No. 6, 01.01.2002, p. 649-652.

Research output: Contribution to journalArticle

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