The association of maternal prenatal IgE and eczema in offspring is restricted to non-atopic mothers

William B. Hicks, Christian G. Nageotte, Ganesa Wegienka, Suzanne Havstad, Christine C. Johnson, Dennis Randall Ownby, Edward M. Zoratti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The risk of developing eczema is thought to be influenced by both genetic and environmental factors. Prenatal factors including the intrauterine environment may influence risk. We examined the relationship of maternal total IgE obtained during pregnancy to the incidence of atopic dermatitis in their 2-yr-old offspring. Subjects were participants in an unselected Detroit area birth cohort. Serum IgE was measured from 458 mothers in the third trimester of pregnancy along with prenatal family and environmental histories. Children were evaluated at approximately 2yr of age for current or past eczema by maternal questionnaire and physician examination. Among the 458 children, 20.3% (n=93) had a doctor confirmed diagnosis of eczema. Prenatal IgE was higher among women whose children developed AD vs. women whose children did not [Geometric means and 95% confidence intervals 52.7IU/ml (40.9-68.0) vs. 32.9IU/ml (28.0-38.7), p=0.010]. The association was only seen in a subgroup of 181 women without allergic sensitization (specific IgE >0.35IU/ml) to a panel of eight common allergens. Of the women without allergic sensitization, the mean serum IgE was 24.1IU/ml (15.5-37.6) among those whose children had a diagnosis of eczema. The mean serum IgE was 11.2IU/ml (9.2-13.6) among those whose children did not have a diagnosis of eczema (p-value 0.002). Maternal prenatal IgE level among women who are not sensitized to common allergens is associated with increased risk of eczema in offspring.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalPediatric Allergy and Immunology
Volume22
Issue number7
DOIs
StatePublished - Nov 1 2011

Fingerprint

Eczema
Immunoglobulin E
Mothers
Allergens
Serum
Third Pregnancy Trimester
Atopic Dermatitis
Parturition
Confidence Intervals
Physicians
Pregnancy
Incidence

Keywords

  • Atopic dermatitis
  • Eczema
  • IgE
  • Maternal atopy
  • Prenatal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cite this

The association of maternal prenatal IgE and eczema in offspring is restricted to non-atopic mothers. / Hicks, William B.; Nageotte, Christian G.; Wegienka, Ganesa; Havstad, Suzanne; Johnson, Christine C.; Ownby, Dennis Randall; Zoratti, Edward M.

In: Pediatric Allergy and Immunology, Vol. 22, No. 7, 01.11.2011, p. 684-687.

Research output: Contribution to journalArticle

Hicks, William B. ; Nageotte, Christian G. ; Wegienka, Ganesa ; Havstad, Suzanne ; Johnson, Christine C. ; Ownby, Dennis Randall ; Zoratti, Edward M. / The association of maternal prenatal IgE and eczema in offspring is restricted to non-atopic mothers. In: Pediatric Allergy and Immunology. 2011 ; Vol. 22, No. 7. pp. 684-687.
@article{67c61ba531ad43f09ef2014cfde10c42,
title = "The association of maternal prenatal IgE and eczema in offspring is restricted to non-atopic mothers",
abstract = "The risk of developing eczema is thought to be influenced by both genetic and environmental factors. Prenatal factors including the intrauterine environment may influence risk. We examined the relationship of maternal total IgE obtained during pregnancy to the incidence of atopic dermatitis in their 2-yr-old offspring. Subjects were participants in an unselected Detroit area birth cohort. Serum IgE was measured from 458 mothers in the third trimester of pregnancy along with prenatal family and environmental histories. Children were evaluated at approximately 2yr of age for current or past eczema by maternal questionnaire and physician examination. Among the 458 children, 20.3{\%} (n=93) had a doctor confirmed diagnosis of eczema. Prenatal IgE was higher among women whose children developed AD vs. women whose children did not [Geometric means and 95{\%} confidence intervals 52.7IU/ml (40.9-68.0) vs. 32.9IU/ml (28.0-38.7), p=0.010]. The association was only seen in a subgroup of 181 women without allergic sensitization (specific IgE >0.35IU/ml) to a panel of eight common allergens. Of the women without allergic sensitization, the mean serum IgE was 24.1IU/ml (15.5-37.6) among those whose children had a diagnosis of eczema. The mean serum IgE was 11.2IU/ml (9.2-13.6) among those whose children did not have a diagnosis of eczema (p-value 0.002). Maternal prenatal IgE level among women who are not sensitized to common allergens is associated with increased risk of eczema in offspring.",
keywords = "Atopic dermatitis, Eczema, IgE, Maternal atopy, Prenatal",
author = "Hicks, {William B.} and Nageotte, {Christian G.} and Ganesa Wegienka and Suzanne Havstad and Johnson, {Christine C.} and Ownby, {Dennis Randall} and Zoratti, {Edward M.}",
year = "2011",
month = "11",
day = "1",
doi = "10.1111/j.1399-3038.2011.01160.x",
language = "English (US)",
volume = "22",
pages = "684--687",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "7",

}

TY - JOUR

T1 - The association of maternal prenatal IgE and eczema in offspring is restricted to non-atopic mothers

AU - Hicks, William B.

AU - Nageotte, Christian G.

AU - Wegienka, Ganesa

AU - Havstad, Suzanne

AU - Johnson, Christine C.

AU - Ownby, Dennis Randall

AU - Zoratti, Edward M.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - The risk of developing eczema is thought to be influenced by both genetic and environmental factors. Prenatal factors including the intrauterine environment may influence risk. We examined the relationship of maternal total IgE obtained during pregnancy to the incidence of atopic dermatitis in their 2-yr-old offspring. Subjects were participants in an unselected Detroit area birth cohort. Serum IgE was measured from 458 mothers in the third trimester of pregnancy along with prenatal family and environmental histories. Children were evaluated at approximately 2yr of age for current or past eczema by maternal questionnaire and physician examination. Among the 458 children, 20.3% (n=93) had a doctor confirmed diagnosis of eczema. Prenatal IgE was higher among women whose children developed AD vs. women whose children did not [Geometric means and 95% confidence intervals 52.7IU/ml (40.9-68.0) vs. 32.9IU/ml (28.0-38.7), p=0.010]. The association was only seen in a subgroup of 181 women without allergic sensitization (specific IgE >0.35IU/ml) to a panel of eight common allergens. Of the women without allergic sensitization, the mean serum IgE was 24.1IU/ml (15.5-37.6) among those whose children had a diagnosis of eczema. The mean serum IgE was 11.2IU/ml (9.2-13.6) among those whose children did not have a diagnosis of eczema (p-value 0.002). Maternal prenatal IgE level among women who are not sensitized to common allergens is associated with increased risk of eczema in offspring.

AB - The risk of developing eczema is thought to be influenced by both genetic and environmental factors. Prenatal factors including the intrauterine environment may influence risk. We examined the relationship of maternal total IgE obtained during pregnancy to the incidence of atopic dermatitis in their 2-yr-old offspring. Subjects were participants in an unselected Detroit area birth cohort. Serum IgE was measured from 458 mothers in the third trimester of pregnancy along with prenatal family and environmental histories. Children were evaluated at approximately 2yr of age for current or past eczema by maternal questionnaire and physician examination. Among the 458 children, 20.3% (n=93) had a doctor confirmed diagnosis of eczema. Prenatal IgE was higher among women whose children developed AD vs. women whose children did not [Geometric means and 95% confidence intervals 52.7IU/ml (40.9-68.0) vs. 32.9IU/ml (28.0-38.7), p=0.010]. The association was only seen in a subgroup of 181 women without allergic sensitization (specific IgE >0.35IU/ml) to a panel of eight common allergens. Of the women without allergic sensitization, the mean serum IgE was 24.1IU/ml (15.5-37.6) among those whose children had a diagnosis of eczema. The mean serum IgE was 11.2IU/ml (9.2-13.6) among those whose children did not have a diagnosis of eczema (p-value 0.002). Maternal prenatal IgE level among women who are not sensitized to common allergens is associated with increased risk of eczema in offspring.

KW - Atopic dermatitis

KW - Eczema

KW - IgE

KW - Maternal atopy

KW - Prenatal

UR - http://www.scopus.com/inward/record.url?scp=80053118886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053118886&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3038.2011.01160.x

DO - 10.1111/j.1399-3038.2011.01160.x

M3 - Article

VL - 22

SP - 684

EP - 687

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 7

ER -