The autoimmune regulator (Aire) controls iNKT cell development and maturation

Qing Sheng Mi; Zhong Bin Deng; Sunil K. Joshi; Zai Zhao Wang; Li Zhou; Sarah Eckenrode; Ratanmani Joshi; Dalam Ly; Bing Yi; Terry L. Delovitch; Jin-Xiong She

doi:10.1038/nm1424

The autoimmune regulator (Aire) controls iNKT cell development and maturation

Qing Sheng Mi, Zhong Bin Deng, Sunil K. Joshi, Zai Zhao Wang, Li Zhou, Sarah Eckenrode, Ratanmani Joshi, Dalam Ly, Bing Yi, Terry L. Delovitch, Jin-Xiong She

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.

Original language	English (US)
Pages (from-to)	624-626
Number of pages	3
Journal	Nature Medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1038/nm1424
State	Published - Jun 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1038/nm1424

Fingerprint Dive into the research topics of 'The autoimmune regulator (Aire) controls iNKT cell development and maturation'. Together they form a unique fingerprint.

Cite this

The autoimmune regulator (Aire) controls iNKT cell development and maturation. / Mi, Qing Sheng; Deng, Zhong Bin; Joshi, Sunil K.; Wang, Zai Zhao; Zhou, Li; Eckenrode, Sarah; Joshi, Ratanmani; Ly, Dalam; Yi, Bing; Delovitch, Terry L.; She, Jin-Xiong.

In: Nature Medicine, Vol. 12, No. 6, 06.2006, p. 624-626.

Research output: Contribution to journal › Article › peer-review

@article{e08f1db23b2b47bf85aa4739601f3cf3,

title = "The autoimmune regulator (Aire) controls iNKT cell development and maturation",

abstract = "The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.",

author = "Mi, {Qing Sheng} and Deng, {Zhong Bin} and Joshi, {Sunil K.} and Wang, {Zai Zhao} and Li Zhou and Sarah Eckenrode and Ratanmani Joshi and Dalam Ly and Bing Yi and Delovitch, {Terry L.} and Jin-Xiong She",

year = "2006",

month = jun,

doi = "10.1038/nm1424",

language = "English (US)",

volume = "12",

pages = "624--626",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "6",

}

TY - JOUR

T1 - The autoimmune regulator (Aire) controls iNKT cell development and maturation

AU - Mi, Qing Sheng

AU - Deng, Zhong Bin

AU - Joshi, Sunil K.

AU - Wang, Zai Zhao

AU - Zhou, Li

AU - Eckenrode, Sarah

AU - Joshi, Ratanmani

AU - Ly, Dalam

AU - Yi, Bing

AU - Delovitch, Terry L.

AU - She, Jin-Xiong

PY - 2006/6

Y1 - 2006/6

N2 - The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.

AB - The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.

UR - http://www.scopus.com/inward/record.url?scp=33744988740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744988740&partnerID=8YFLogxK

U2 - 10.1038/nm1424

DO - 10.1038/nm1424

M3 - Article

C2 - 16732280

AN - SCOPUS:33744988740

VL - 12

SP - 624

EP - 626

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 6

ER -