Abstract
The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.
Original language | English (US) |
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Pages (from-to) | 624-626 |
Number of pages | 3 |
Journal | Nature Medicine |
Volume | 12 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2006 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)