@article{e08f1db23b2b47bf85aa4739601f3cf3,
title = "The autoimmune regulator (Aire) controls iNKT cell development and maturation",
abstract = "The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.",
author = "Mi, {Qing Sheng} and Deng, {Zhong Bin} and Joshi, {Sunil K.} and Wang, {Zai Zhao} and Li Zhou and Sarah Eckenrode and Ratanmani Joshi and Dalam Ly and Bing Yi and Delovitch, {Terry L.} and Jin-Xiong She",
note = "Funding Information: We thank R. Brutkiewicz and K. Hayakawa for the gifts of NKT cell lines, L. Peltonen for providing the initial Aire−/− mice and Kirin Brewery Pharmaceutical Co. for a-GalCer. We acknowledge H. He for his assistance with artwork. This work was supported in part by grants from the American Diabetes Association (to Q.-S.M.), the Juvenile Diabetes Research Foundation International (to Q.-S.M.), the US National Institutes of Health (to J.-X.S.) and the Canadian Institutes of Health Research (to T.L.D.).",
year = "2006",
month = jun,
doi = "10.1038/nm1424",
language = "English (US)",
volume = "12",
pages = "624--626",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "6",
}