The autoimmune regulator (Aire) controls iNKT cell development and maturation

Qing Sheng Mi, Zhong Bin Deng, Sunil K. Joshi, Zai Zhao Wang, Li Zhou, Sarah Eckenrode, Ratanmani Joshi, Dalam Ly, Bing Yi, Terry L. Delovitch, Jin-Xiong She

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.

Original languageEnglish (US)
Pages (from-to)624-626
Number of pages3
JournalNature Medicine
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 1 2006

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mi, Q. S., Deng, Z. B., Joshi, S. K., Wang, Z. Z., Zhou, L., Eckenrode, S., ... She, J-X. (2006). The autoimmune regulator (Aire) controls iNKT cell development and maturation. Nature Medicine, 12(6), 624-626. https://doi.org/10.1038/nm1424