Abstract
The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 624-626 |
| Number of pages | 3 |
| Journal | Nature Medicine |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2006 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The autoimmune regulator (Aire) controls iNKT cell development and maturation. / Mi, Qing Sheng; Deng, Zhong Bin; Joshi, Sunil K.; Wang, Zai Zhao; Zhou, Li; Eckenrode, Sarah; Joshi, Ratanmani; Ly, Dalam; Yi, Bing; Delovitch, Terry L.; She, Jin-Xiong.
In: Nature Medicine, Vol. 12, No. 6, 01.06.2006, p. 624-626.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The autoimmune regulator (Aire) controls iNKT cell development and maturation
AU - Mi, Qing Sheng
AU - Deng, Zhong Bin
AU - Joshi, Sunil K.
AU - Wang, Zai Zhao
AU - Zhou, Li
AU - Eckenrode, Sarah
AU - Joshi, Ratanmani
AU - Ly, Dalam
AU - Yi, Bing
AU - Delovitch, Terry L.
AU - She, Jin-Xiong
PY - 2006/6/1
Y1 - 2006/6/1
N2 - The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.
AB - The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.
UR - http://www.scopus.com/inward/record.url?scp=33744988740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744988740&partnerID=8YFLogxK
U2 - 10.1038/nm1424
DO - 10.1038/nm1424
M3 - Article
C2 - 16732280
AN - SCOPUS:33744988740
VL - 12
SP - 624
EP - 626
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 6
ER -