The autoimmune regulator (Aire) controls iNKT cell development and maturation

Qing Sheng Mi; Zhong Bin Deng; Sunil K. Joshi; Zai Zhao Wang; Li Zhou; Sarah Eckenrode; Ratanmani Joshi; Dalam Ly; Bing Yi; Terry L. Delovitch; Jin-Xiong She

doi:10.1038/nm1424

The autoimmune regulator (Aire) controls iNKT cell development and maturation

Qing Sheng Mi, Zhong Bin Deng, Sunil K. Joshi, Zai Zhao Wang, Li Zhou, Sarah Eckenrode, Ratanmani Joshi, Dalam Ly, Bing Yi, Terry L. Delovitch, Jin-Xiong She

Obstetrics and Gynecology

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.

Original language	English (US)
Pages (from-to)	624-626
Number of pages	3
Journal	Nature Medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1038/nm1424
State	Published - Jun 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1038/nm1424

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Mi, Q. S., Deng, Z. B., Joshi, S. K., Wang, Z. Z., Zhou, L., Eckenrode, S., Joshi, R., Ly, D., Yi, B., Delovitch, T. L., & She, J-X. (2006). The autoimmune regulator (Aire) controls iNKT cell development and maturation. Nature Medicine, 12(6), 624-626. https://doi.org/10.1038/nm1424

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abstract = "The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.",

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AU - Eckenrode, Sarah

AU - Joshi, Ratanmani

AU - Ly, Dalam

AU - Yi, Bing

AU - Delovitch, Terry L.

AU - She, Jin-Xiong

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