La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein

Translated title of the contribution: The cancer stem cell: The breast cancer driver

Christophe Ginestier, Hasan Korkaya, Gabriela Dontu, Daniel Birnbaum, Max S. Wicha, Emmanuelle Charafe-Jauffret

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.

Original languageFrench
Pages (from-to)1133-1139
Number of pages7
JournalMedecine/Sciences
Volume23
Issue number12
Publication statusPublished - Dec 1 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ginestier, C., Korkaya, H., Dontu, G., Birnbaum, D., Wicha, M. S., & Charafe-Jauffret, E. (2007). La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein. Medecine/Sciences, 23(12), 1133-1139.