Abstract
Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
| Original language | French |
|---|---|
| Pages (from-to) | 1133-1139 |
| Number of pages | 7 |
| Journal | Medecine/Sciences |
| Volume | 23 |
| Issue number | 12 |
| Publication status | Published - Dec 1 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Ginestier, C., Korkaya, H., Dontu, G., Birnbaum, D., Wicha, M. S., & Charafe-Jauffret, E. (2007). La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein. Medecine/Sciences, 23(12), 1133-1139.