TY - JOUR
T1 - La cellule souche cancéreuse
T2 - Un pilote aux commandes du cancer du sein
AU - Ginestier, Christophe
AU - Korkaya, Hasan
AU - Dontu, Gabriela
AU - Birnbaum, Daniel
AU - Wicha, Max S.
AU - Charafe-Jauffret, Emmanuelle
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2007/12
Y1 - 2007/12
N2 - Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
AB - Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
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U2 - 10.1051/medsci/200723121133
DO - 10.1051/medsci/200723121133
M3 - Review article
C2 - 18154716
AN - SCOPUS:37849031304
VL - 23
SP - 1133
EP - 1139
JO - Medecine/Sciences
JF - Medecine/Sciences
SN - 0767-0974
IS - 12
ER -