La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein

Christophe Ginestier; Hasan Korkaya; Gabriela Dontu; Daniel Birnbaum; Max S. Wicha; Emmanuelle Charafe-Jauffret

doi:10.1051/medsci/200723121133

La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein

Translated title of the contribution: The cancer stem cell: The breast cancer driver

Christophe Ginestier, Hasan Korkaya, Gabriela Dontu, Daniel Birnbaum, Max S. Wicha, Emmanuelle Charafe-Jauffret

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44⁺CD24^-/lowlin^- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.

Translated title of the contribution	The cancer stem cell: The breast cancer driver
Original language	French
Pages (from-to)	1133-1139
Number of pages	7
Journal	Medecine/Sciences
Volume	23
Issue number	12
DOIs	https://doi.org/10.1051/medsci/200723121133
State	Published - Dec 2007
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "La cellule souche canc{\'e}reuse: Un pilote aux commandes du cancer du sein",

abstract = "Recent research in a large variety of tumors, including breast cancer, has given support to the {"}cancer stem cell hypothesis{"}. Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.",

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AU - Dontu, Gabriela

AU - Birnbaum, Daniel

AU - Wicha, Max S.

AU - Charafe-Jauffret, Emmanuelle

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