Abstract
Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
| Original language | French |
|---|---|
| Pages (from-to) | 1133-1139 |
| Number of pages | 7 |
| Journal | Medecine/Sciences |
| Volume | 23 |
| Issue number | 12 |
| State | Published - Dec 1 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
La cellule souche cancéreuse : Un pilote aux commandes du cancer du sein. / Ginestier, Christophe; Korkaya, Hasan; Dontu, Gabriela; Birnbaum, Daniel; Wicha, Max S.; Charafe-Jauffret, Emmanuelle.
In: Medecine/Sciences, Vol. 23, No. 12, 01.12.2007, p. 1133-1139.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - La cellule souche cancéreuse
T2 - Un pilote aux commandes du cancer du sein
AU - Ginestier, Christophe
AU - Korkaya, Hasan
AU - Dontu, Gabriela
AU - Birnbaum, Daniel
AU - Wicha, Max S.
AU - Charafe-Jauffret, Emmanuelle
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
AB - Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
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UR - http://www.scopus.com/inward/citedby.url?scp=37849031304&partnerID=8YFLogxK
M3 - Review article
C2 - 18154716
AN - SCOPUS:37849031304
VL - 23
SP - 1133
EP - 1139
JO - Medecine/Sciences
JF - Medecine/Sciences
SN - 0767-0974
IS - 12
ER -