The Cardiovascular Clock

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses the importance of the circadian clock and circadian rhythms with regard to their significance in cardiovascular cell signaling, blood pressure control, vascular function, and disease based on insights from human physiology and experimental animal models. Signals with established roles in the control of vascular contractility, tone, and remodeling also impart a significant influence on the circadian clock. These include endothelin, prostanoids, angiotensin (AT), and even nitric oxide (NO). The disturbances in blood pressure rhythm cause increased cardiovascular disease and death. Recent basic science studies have further implicated the circadian clock in the control of blood pressure. While obesity and metabolic dysfunction are major risk factors for the impaired control of blood pressure, recent evidence has also implicated the circadian clock. There are different animal models with mutations in renin-angiotensin system (RAS) pathway that exhibit hypertension and defects in blood pressure circadian rhythm.

Original languageEnglish (US)
Title of host publicationCircadian Medicine
PublisherWiley-Blackwell
Pages119-133
Number of pages15
ISBN (Electronic)9781118467831
ISBN (Print)9781118467787
DOIs
StatePublished - May 8 2015

Fingerprint

Circadian Clocks
Blood Pressure
Circadian Rhythm
Animal Models
Endothelins
Angiotensins
Renin-Angiotensin System
Vascular Diseases
Prostaglandins
Blood Vessels
Nitric Oxide
Cardiovascular Diseases
Obesity
Hypertension
Mutation

Keywords

  • Blood pressure
  • Cardiovascular clock
  • Cardiovascular disease
  • Circadian rhythm
  • ENOS signaling
  • Endothelial cell layer
  • Hypertension
  • Obesity
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Rudic, R. D. (2015). The Cardiovascular Clock. In Circadian Medicine (pp. 119-133). Wiley-Blackwell. https://doi.org/10.1002/9781118467831.ch8

The Cardiovascular Clock. / Rudic, Radu Daniel.

Circadian Medicine. Wiley-Blackwell, 2015. p. 119-133.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rudic, RD 2015, The Cardiovascular Clock. in Circadian Medicine. Wiley-Blackwell, pp. 119-133. https://doi.org/10.1002/9781118467831.ch8
Rudic RD. The Cardiovascular Clock. In Circadian Medicine. Wiley-Blackwell. 2015. p. 119-133 https://doi.org/10.1002/9781118467831.ch8
Rudic, Radu Daniel. / The Cardiovascular Clock. Circadian Medicine. Wiley-Blackwell, 2015. pp. 119-133
@inbook{f2a57725127d4b6a8aa8bc53dc973346,
title = "The Cardiovascular Clock",
abstract = "This chapter discusses the importance of the circadian clock and circadian rhythms with regard to their significance in cardiovascular cell signaling, blood pressure control, vascular function, and disease based on insights from human physiology and experimental animal models. Signals with established roles in the control of vascular contractility, tone, and remodeling also impart a significant influence on the circadian clock. These include endothelin, prostanoids, angiotensin (AT), and even nitric oxide (NO). The disturbances in blood pressure rhythm cause increased cardiovascular disease and death. Recent basic science studies have further implicated the circadian clock in the control of blood pressure. While obesity and metabolic dysfunction are major risk factors for the impaired control of blood pressure, recent evidence has also implicated the circadian clock. There are different animal models with mutations in renin-angiotensin system (RAS) pathway that exhibit hypertension and defects in blood pressure circadian rhythm.",
keywords = "Blood pressure, Cardiovascular clock, Cardiovascular disease, Circadian rhythm, ENOS signaling, Endothelial cell layer, Hypertension, Obesity, Renin-angiotensin system",
author = "Rudic, {Radu Daniel}",
year = "2015",
month = "5",
day = "8",
doi = "10.1002/9781118467831.ch8",
language = "English (US)",
isbn = "9781118467787",
pages = "119--133",
booktitle = "Circadian Medicine",
publisher = "Wiley-Blackwell",
address = "United States",

}

TY - CHAP

T1 - The Cardiovascular Clock

AU - Rudic, Radu Daniel

PY - 2015/5/8

Y1 - 2015/5/8

N2 - This chapter discusses the importance of the circadian clock and circadian rhythms with regard to their significance in cardiovascular cell signaling, blood pressure control, vascular function, and disease based on insights from human physiology and experimental animal models. Signals with established roles in the control of vascular contractility, tone, and remodeling also impart a significant influence on the circadian clock. These include endothelin, prostanoids, angiotensin (AT), and even nitric oxide (NO). The disturbances in blood pressure rhythm cause increased cardiovascular disease and death. Recent basic science studies have further implicated the circadian clock in the control of blood pressure. While obesity and metabolic dysfunction are major risk factors for the impaired control of blood pressure, recent evidence has also implicated the circadian clock. There are different animal models with mutations in renin-angiotensin system (RAS) pathway that exhibit hypertension and defects in blood pressure circadian rhythm.

AB - This chapter discusses the importance of the circadian clock and circadian rhythms with regard to their significance in cardiovascular cell signaling, blood pressure control, vascular function, and disease based on insights from human physiology and experimental animal models. Signals with established roles in the control of vascular contractility, tone, and remodeling also impart a significant influence on the circadian clock. These include endothelin, prostanoids, angiotensin (AT), and even nitric oxide (NO). The disturbances in blood pressure rhythm cause increased cardiovascular disease and death. Recent basic science studies have further implicated the circadian clock in the control of blood pressure. While obesity and metabolic dysfunction are major risk factors for the impaired control of blood pressure, recent evidence has also implicated the circadian clock. There are different animal models with mutations in renin-angiotensin system (RAS) pathway that exhibit hypertension and defects in blood pressure circadian rhythm.

KW - Blood pressure

KW - Cardiovascular clock

KW - Cardiovascular disease

KW - Circadian rhythm

KW - ENOS signaling

KW - Endothelial cell layer

KW - Hypertension

KW - Obesity

KW - Renin-angiotensin system

UR - http://www.scopus.com/inward/record.url?scp=85018814425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018814425&partnerID=8YFLogxK

U2 - 10.1002/9781118467831.ch8

DO - 10.1002/9781118467831.ch8

M3 - Chapter

AN - SCOPUS:85018814425

SN - 9781118467787

SP - 119

EP - 133

BT - Circadian Medicine

PB - Wiley-Blackwell

ER -