The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste

An in vitro study

Z. Wang, T. Jiang, S. Sauro, David Henry Pashley, M. Toledano, R. Osorio, S. Liang, W. Xing, Y. Sa, Y. Wang

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization. Methods: Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis. Results: The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR/FTIR and EDX revealed increased mineral content after treatment with Novamin. Conclusions: As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalAustralian Dental Journal
Volume56
Issue number4
DOIs
StatePublished - Dec 1 2011

Fingerprint

Toothpastes
Dentin
Glass
Dentin Permeability
Dentin Sensitivity
Electron Scanning Microscopy
Acids
Minerals
X-Rays
Diamines
Fourier Analysis
Fourier Transform Infrared Spectroscopy
Citric Acid
In Vitro Techniques
Water

Keywords

  • Bioactive glass
  • attenuated total reflection Fourier transformed infrared spectroscopy
  • dentine hypersensitivity
  • energy dispersive X-ray
  • scanning electron microscopy
  • toothpaste

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste : An in vitro study. / Wang, Z.; Jiang, T.; Sauro, S.; Pashley, David Henry; Toledano, M.; Osorio, R.; Liang, S.; Xing, W.; Sa, Y.; Wang, Y.

In: Australian Dental Journal, Vol. 56, No. 4, 01.12.2011, p. 372-381.

Research output: Contribution to journalArticle

Wang, Z, Jiang, T, Sauro, S, Pashley, DH, Toledano, M, Osorio, R, Liang, S, Xing, W, Sa, Y & Wang, Y 2011, 'The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: An in vitro study', Australian Dental Journal, vol. 56, no. 4, pp. 372-381. https://doi.org/10.1111/j.1834-7819.2011.01361.x
Wang, Z. ; Jiang, T. ; Sauro, S. ; Pashley, David Henry ; Toledano, M. ; Osorio, R. ; Liang, S. ; Xing, W. ; Sa, Y. ; Wang, Y. / The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste : An in vitro study. In: Australian Dental Journal. 2011 ; Vol. 56, No. 4. pp. 372-381.
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