The distribution of pyrimidine tracts in DNA can be calculated from nearest neighbor frequencies

John Texter, John C. Sutherland

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Statistical analysis of DNA base sequences generated from nearest neighbor frequencies by a Monte Carlo technique yields distributions of pyrimidine tracts in good agreement with experimental results. Better agreement with experiment is obtained with nearest-neighbor-frequency based calculations than with calculations based on base composition which assume random base arrangements. The nearest-neighbor-frequency method can also be applied to the analysis of high resolution thermal denaturation profiles, the sequence specific interaction of drugs and proteins, and the distribution of photoproducts produced in DNA by ultraviolet radiation.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalJournal of Theoretical Biology
Volume75
Issue number3
DOIs
StatePublished - Dec 7 1978
Externally publishedYes

Fingerprint

pyrimidines
Nearest Neighbor
DNA
Denaturation
Base Composition
Drug Interactions
Ultraviolet radiation
drug interactions
Statistical methods
Monte Carlo Techniques
Hot Temperature
Radiation
Proteins
denaturation
Ultraviolet
Statistical Analysis
ultraviolet radiation
Arrangement
Drugs
statistical analysis

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

The distribution of pyrimidine tracts in DNA can be calculated from nearest neighbor frequencies. / Texter, John; Sutherland, John C.

In: Journal of Theoretical Biology, Vol. 75, No. 3, 07.12.1978, p. 263-269.

Research output: Contribution to journalArticle

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