Statistical analysis of DNA base sequences generated from nearest neighbor frequencies by a Monte Carlo technique yields distributions of pyrimidine tracts in good agreement with experimental results. Better agreement with experiment is obtained with nearest-neighbor-frequency based calculations than with calculations based on base composition which assume random base arrangements. The nearest-neighbor-frequency method can also be applied to the analysis of high resolution thermal denaturation profiles, the sequence specific interaction of drugs and proteins, and the distribution of photoproducts produced in DNA by ultraviolet radiation.
ASJC Scopus subject areas
- Statistics and Probability
- Modeling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics