The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy

Hai Wang, Yu Chen Du, Xiao Jun Zhou, Hong Liu, Shou-Ching Tang

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The major functions of Hippo (Hpo) signaling pathway are to control cell growth, proliferation, and apoptosis. As its important downstream player, yes-associated protein (YAP)-1 was originally found to promote cell proliferation and transformation. Overexpression of YAP-1 has been linked to tumor progression and worse survival in certain malignancies. However, it has been recently recognized as a tumor suppressor gene as well since it also induces apoptosis. Decreased or absent expression of YAP-1 is highly correlated with tumor progression and worse survival in other tumors such as breast cancer. It is clear that YAP-1 plays a dual role as oncogene and tumor suppressor gene in human oncogenesis, depending on the specific tissue type involved. Here, we reviewed the recent research on both the oncogenic and tumor suppressor function of YAP-1 and its significance in human malignancy. The clinical implication of YAP-1 expression in cancer prognosis and the development of targeted therapy will also be discussed.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalCancer and Metastasis Reviews
Volume33
Issue number1
DOIs
StatePublished - Mar 2014

Keywords

  • Solid tumors
  • Survival and targeted therapy
  • Tumor suppressor and oncogene
  • YAP-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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