The dual role of TNF in pulmonary edema

Guang Yang, Jurg Hamacher, Boris A Gorshkov, Richard White, Supriya Sridhar, Alexander Dmitriyevich Verin, Trinad Chakraborty, Rudolf Lucas

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Pulmonary edema, a major manifestation of left ventricular heart failure, renal insufficiency, shock, diffuse alveolar damage and lung hypersensitivity states, is a significant medical problem worldwide and can be life-threatening. The proinflammatory cytokine tumor necrosis factor (TNF) has been shown to contribute to the pathogenesis and development of pulmonary edema. However, some recent studies have demonstrated surprisingly that TNF can also promote alveolar fluid reabsorption in vivo and in vitro. This protective effect of the cytokine is mediated by the lectin-like domain of the cytokine, which is spatially distinct from the TNF receptor binding sites. The TIP peptide, a synthetic mimic of the lectinlike domain of TNF, can significantly increase alveolar fluid clearance and improve lung compliance in pulmonary edema models. In this review, we will discuss the dual role of TNF in pulmonary edema. Abbreviations:-tumor necrosis factor (TNF);acute lung injury (ALI);acute respiratory distress syndrome (ARDS);positive end-expiratory pressure (PEEP);epithelial sodium channel (ENaC);neural precursor cell-expressed developmentally downregulated (gene 4) protein (Nedd4-2);serum and glucocorticoid dependent kinase (Sgk-1);insulin-like growth factor 1 (IGF-1);Protein Kinase C (PKC);reactive oxygen species (ROS);myosin light chain (MLC);pneumolysin (PLY);listeriolysin (LLO);interleukin (IL);bronchoalveolar lavage fluids (BALF);Bacillus Calmette-Guerin (BCG);TNF receptor type 1 (TNFR1);TNF receptor type 2 (TNF-R2);.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalJournal of Cardiovascular Disease Research
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2010

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Pulmonary Edema
Tumor Necrosis Factor-alpha
Cytokines
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Epithelial Sodium Channels
Lung Compliance
Myosin Light Chains
Positive-Pressure Respiration
Acute Lung Injury
Tumor Necrosis Factor Receptors
Interleukins
Adult Respiratory Distress Syndrome
Bronchoalveolar Lavage Fluid
Somatomedins
Mycobacterium bovis
Lectins
Protein Kinase C
Glucocorticoids
Renal Insufficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The dual role of TNF in pulmonary edema. / Yang, Guang; Hamacher, Jurg; Gorshkov, Boris A; White, Richard; Sridhar, Supriya; Verin, Alexander Dmitriyevich; Chakraborty, Trinad; Lucas, Rudolf.

In: Journal of Cardiovascular Disease Research, Vol. 1, No. 1, 01.01.2010, p. 29-36.

Research output: Contribution to journalReview article

Yang, G, Hamacher, J, Gorshkov, BA, White, R, Sridhar, S, Verin, AD, Chakraborty, T & Lucas, R 2010, 'The dual role of TNF in pulmonary edema', Journal of Cardiovascular Disease Research, vol. 1, no. 1, pp. 29-36. https://doi.org/10.4103/0975-3583.59983
Yang, Guang ; Hamacher, Jurg ; Gorshkov, Boris A ; White, Richard ; Sridhar, Supriya ; Verin, Alexander Dmitriyevich ; Chakraborty, Trinad ; Lucas, Rudolf. / The dual role of TNF in pulmonary edema. In: Journal of Cardiovascular Disease Research. 2010 ; Vol. 1, No. 1. pp. 29-36.
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