The effect of ε-Aminocaproic acid on perioperative blood loss in patients with idiopathic scoliosis undergoing posterior spinal fusion

A Preliminary prospective study

Ivan Florentino, Laurel C. Blakemore, George H. Thompson, Connie Poe-Kochert, Patricia Adler, Paul Tripi

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Study Design. A prospective study evaluating the efficacy of ε-aminocaproic acid (EACA) in decreasing perioperative blood loss in idiopathic scoliosis. Objectives. To compare the perioperative blood loss and need for blood replacement in two groups of patients undergoing surgery for idiopathic scoliosis. One group received intraoperative EACA; the other did not and served as controls. Summary of Background Data. Excessive blood loss increases the operative time, risk for blood product disease transmission, postoperative complications, and costs associated with posterior spinal fusion and instrumentation. EACA is an antifibrinolytic agent that has been shown to be effective in reducing perioperative blood loss during pediatric cardiothoracic surgical procedures. We hypothesized that it would also be effective in lowering blood loss during posterior spinal fusion for idiopathic scoliosis. Methods. We compared the perioperative blood loss of 28 consecutive pediatric patients with idiopathic scoliosis who underwent posterior spinal fusion and received intraoperative EACA with 31 consecutive patients who did not receive this medication and served as a control group. Results. The patients in both groups were similar. Patients in the EACA group demonstrated statistically significant decreases in total estimated perioperative blood loss and the need for autologous blood transfusion. The patients in the EACA group had no intraoperative or post-operative complications related to the use of this medication. Conclusions. Based on these preliminary findings, we believe that EACA is helpful in decreasing blood loss in patients undergoing posterior spinal fusion and instrumentation, and may decrease the number of autologous units needed to maintain safe perioperative hemoglobin levels, thereby improving safety and lowering cost associated with scoliosis surgery.

Original languageEnglish (US)
Pages (from-to)1147-1151
Number of pages5
JournalSpine
Volume26
Issue number10
DOIs
StatePublished - May 15 2001
Externally publishedYes

Fingerprint

Aminocaproic Acid
Spinal Fusion
Scoliosis
Prospective Studies
Pediatrics
Autologous Blood Transfusions
Costs and Cost Analysis
Antifibrinolytic Agents
Hematologic Diseases
Operative Time
Hemoglobins
Safety
Control Groups

Keywords

  • ε-aminocaproic acid
  • Idiopathic scoliosis
  • Perioperative blood loss

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

The effect of ε-Aminocaproic acid on perioperative blood loss in patients with idiopathic scoliosis undergoing posterior spinal fusion : A Preliminary prospective study. / Florentino, Ivan; Blakemore, Laurel C.; Thompson, George H.; Poe-Kochert, Connie; Adler, Patricia; Tripi, Paul.

In: Spine, Vol. 26, No. 10, 15.05.2001, p. 1147-1151.

Research output: Contribution to journalArticle

Florentino, Ivan ; Blakemore, Laurel C. ; Thompson, George H. ; Poe-Kochert, Connie ; Adler, Patricia ; Tripi, Paul. / The effect of ε-Aminocaproic acid on perioperative blood loss in patients with idiopathic scoliosis undergoing posterior spinal fusion : A Preliminary prospective study. In: Spine. 2001 ; Vol. 26, No. 10. pp. 1147-1151.
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