The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

Uwe Frey, Henry Matthies, Klaus G. Reymann, Hansjürgen Matthies

Research output: Contribution to journalArticle

233 Scopus citations

Abstract

The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalNeuroscience Letters
Volume129
Issue number1
DOIs
StatePublished - Aug 5 1991

Keywords

  • D receptor
  • Dopamine
  • Hippocampal CA1
  • Long-term potentiation
  • Maintenance of long-term potentiation
  • Neuroleptics

ASJC Scopus subject areas

  • Neuroscience(all)

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