The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

Uwe Frey; Henry Matthies; Klaus G. Reymann; Hansjürgen Matthies

doi:10.1016/0304-3940(91)90732-9

The effect of dopaminergic D₁ receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

Uwe Frey, Henry Matthies, Klaus G. Reymann, Hansjürgen Matthies

Neurology

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239 Scopus citations

Abstract

The effect of dopaminergic D₁ receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D₁ receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Neuroscience Letters
Volume	129
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90732-9
State	Published - Aug 5 1991

Keywords

D receptor
Dopamine
Hippocampal CA1
Long-term potentiation
Maintenance of long-term potentiation
Neuroleptics

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(91)90732-9

Cite this

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title = "The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro",

abstract = "The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.",

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AU - Matthies, Hansjürgen

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