The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

Julietta Uta Frey, Henry Matthies, Klaus G. Reymann, Hansjürgen Matthies

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalNeuroscience Letters
Volume129
Issue number1
DOIs
StatePublished - Aug 5 1991

Fingerprint

Long-Term Potentiation
Hippocampal CA1 Region
Excitatory Postsynaptic Potentials
Baths
Population
In Vitro Techniques
SCH 23390

Keywords

  • D receptor
  • Dopamine
  • Hippocampal CA1
  • Long-term potentiation
  • Maintenance of long-term potentiation
  • Neuroleptics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro. / Frey, Julietta Uta; Matthies, Henry; Reymann, Klaus G.; Matthies, Hansjürgen.

In: Neuroscience Letters, Vol. 129, No. 1, 05.08.1991, p. 111-114.

Research output: Contribution to journalArticle

Frey, Julietta Uta ; Matthies, Henry ; Reymann, Klaus G. ; Matthies, Hansjürgen. / The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro. In: Neuroscience Letters. 1991 ; Vol. 129, No. 1. pp. 111-114.
@article{2cacfcf74e7f4119b1236896ed1237e7,
title = "The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro",
abstract = "The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.",
keywords = "D receptor, Dopamine, Hippocampal CA1, Long-term potentiation, Maintenance of long-term potentiation, Neuroleptics",
author = "Frey, {Julietta Uta} and Henry Matthies and Reymann, {Klaus G.} and Hansj{\"u}rgen Matthies",
year = "1991",
month = "8",
day = "5",
doi = "10.1016/0304-3940(91)90732-9",
language = "English (US)",
volume = "129",
pages = "111--114",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

AU - Frey, Julietta Uta

AU - Matthies, Henry

AU - Reymann, Klaus G.

AU - Matthies, Hansjürgen

PY - 1991/8/5

Y1 - 1991/8/5

N2 - The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.

AB - The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 μM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (> 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.

KW - D receptor

KW - Dopamine

KW - Hippocampal CA1

KW - Long-term potentiation

KW - Maintenance of long-term potentiation

KW - Neuroleptics

UR - http://www.scopus.com/inward/record.url?scp=0025923293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025923293&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(91)90732-9

DO - 10.1016/0304-3940(91)90732-9

M3 - Article

C2 - 1833673

AN - SCOPUS:0025923293

VL - 129

SP - 111

EP - 114

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -