The effects of imatinib on pregnancy outcome

Seonaid M. Pye, Jorge Cortes, Patricia Ault, Alan Hatfield, Hagop Kantarjian, Richard Pilot, Gianantonio Rosti, Jane R. Apperley

Research output: Contribution to journalArticle

224 Scopus citations

Abstract

Imatinib has now been in use for almost 10 years. Despite this cumulative experience, little is known about its effects on pregnancy; as a result, there are few published data to facilitate the counseling of women who conceive while taking imatinib. The results we now present provide information which may be of use in such circumstances. Of 180 women exposed to imatinib during pregnancy, outcome data are available for 125 (69%). Of those with known outcomes, 50% delivered normal infants and 28% underwent elective terminations. 3 following the identification of abnormalities. There were a total of 12 infants in whom abnormalities were identified, 3 of which had strikingly similar complex malformations that are clearly a cause for concern. It appears that although most pregnancies exposed to imatinib are likely to have a successful outcome, there remains a risk that exposure may result in serious fetal malformations.

Original languageEnglish (US)
Pages (from-to)5505-5508
Number of pages4
JournalBlood
Volume111
Issue number12
DOIs
StatePublished - Jun 15 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Pye, S. M., Cortes, J., Ault, P., Hatfield, A., Kantarjian, H., Pilot, R., Rosti, G., & Apperley, J. R. (2008). The effects of imatinib on pregnancy outcome. Blood, 111(12), 5505-5508. https://doi.org/10.1182/blood-2007-10-114900