TY - JOUR
T1 - The embryotoxic response to maternal chromium trioxide exposure in different strains of hamsters
AU - Gale, Thomas F.
N1 - Funding Information:
The technical assistance of Mrs. Deanna Cash and the typing skills of Mrs. Rosemary Widener and Mrs. Pat O’Meara are greatly appreciated. This study was supported by NIH Grant RR05365.
PY - 1982/10
Y1 - 1982/10
N2 - This paper compares the chromium trioxide-induced embryotoxic effects among one noninbred (LVG) and five inbred (CB, LHC, LSH, MHA, PD4) strains of hamsters. A single dose of chromium trioxide (8 mg/kg, iv) was injected into pregnant hamsters on the morning of gestation Day 8. Treated and control animals were killed on gestation Day 15 and studied for the types and incidence of external and internal abnormalities, as well as the frequency of resorption sites per uterus. The embryotoxic effects detected in this study include significant rates of resorptions, external abnormalities, cleft palate, and hydrocephalus. The results indicate that the MHA, LSH, and LVG strains are susceptible, while the CB, LHC, and PD4 strains are resistant to chromium trioxide-induced embryotoxicity. This study was compared with prior work in which the same hamster strains were treated with either cadmium, lead, or mercury.
AB - This paper compares the chromium trioxide-induced embryotoxic effects among one noninbred (LVG) and five inbred (CB, LHC, LSH, MHA, PD4) strains of hamsters. A single dose of chromium trioxide (8 mg/kg, iv) was injected into pregnant hamsters on the morning of gestation Day 8. Treated and control animals were killed on gestation Day 15 and studied for the types and incidence of external and internal abnormalities, as well as the frequency of resorption sites per uterus. The embryotoxic effects detected in this study include significant rates of resorptions, external abnormalities, cleft palate, and hydrocephalus. The results indicate that the MHA, LSH, and LVG strains are susceptible, while the CB, LHC, and PD4 strains are resistant to chromium trioxide-induced embryotoxicity. This study was compared with prior work in which the same hamster strains were treated with either cadmium, lead, or mercury.
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U2 - 10.1016/0013-9351(82)90020-2
DO - 10.1016/0013-9351(82)90020-2
M3 - Article
C2 - 7140706
AN - SCOPUS:0020448914
SN - 0013-9351
VL - 29
SP - 196
EP - 203
JO - Environmental Research
JF - Environmental Research
IS - 1
ER -