The endothelial cell nitric oxide synthase: Is it really constitutively expressed?

D. G. Harrison, R. C. Venema, J. F. Arnal, N. Inoue, Y. Ohara, H. Sayegh, T. J. Murphy

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Abstract

During the past two years, the enzyme responsible for production of endothelium-derived nitric oxide, the endothelial cell NO synthase (ecNOS) has been cloned and the gene encoding this enzyme isolated, cloned and its structure characterized. This research has provided direction for a variety of studies of regulation of the ecNOS. Several features of the ecNOS are compatible with a constitutively expressed, poorly regulated gene, including absence of a TATA box and numerous SP-1 sites. The promoter also contains a number of putative binding domains which suggest that it may be regulated by a variety of transcription factor mediated signals. In this review we will discuss evidence to support the concept that the ecNOS is a constitutively expressed gene subject to a modest degree of regulation by important physiological influences.

Original languageEnglish (US)
Pages (from-to)107-117
Number of pages11
JournalAgents and Actions
Volume45
Issue numberSUPPL. I
Publication statusPublished - Jan 22 1995

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Harrison, D. G., Venema, R. C., Arnal, J. F., Inoue, N., Ohara, Y., Sayegh, H., & Murphy, T. J. (1995). The endothelial cell nitric oxide synthase: Is it really constitutively expressed? Agents and Actions, 45(SUPPL. I), 107-117.