The expression of smad signaling pathway in myocardium and potential therapeutic effects

Yuping Duan, Wei Zhu, Min Liu, Muhammad Ashraf, Meifeng Xu

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.

Original languageEnglish (US)
Pages (from-to)651-659
Number of pages9
JournalHistology and Histopathology
Volume32
Issue number7
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

Fingerprint

Smad Proteins
Therapeutic Uses
Myocardium
Bone Morphogenetic Proteins
Myocardial Infarction
Transforming Growth Factors
Protein Transport
Therapeutics

Keywords

  • BMP
  • Myocardial infarction
  • Smad
  • TGF-β

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

The expression of smad signaling pathway in myocardium and potential therapeutic effects. / Duan, Yuping; Zhu, Wei; Liu, Min; Ashraf, Muhammad; Xu, Meifeng.

In: Histology and Histopathology, Vol. 32, No. 7, 01.07.2017, p. 651-659.

Research output: Contribution to journalReview article

Duan, Yuping ; Zhu, Wei ; Liu, Min ; Ashraf, Muhammad ; Xu, Meifeng. / The expression of smad signaling pathway in myocardium and potential therapeutic effects. In: Histology and Histopathology. 2017 ; Vol. 32, No. 7. pp. 651-659.
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