Abstract
Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.
Original language | English (US) |
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Pages (from-to) | 651-659 |
Number of pages | 9 |
Journal | Histology and Histopathology |
Volume | 32 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2017 |
Externally published | Yes |
Keywords
- BMP
- Myocardial infarction
- Smad
- TGF-β
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology