The expression of smad signaling pathway in myocardium and potential therapeutic effects

Yuping Duan, Wei Zhu, Min Liu, Muhammad Ashraf, Meifeng Xu

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.

Original languageEnglish (US)
Pages (from-to)651-659
Number of pages9
JournalHistology and Histopathology
Volume32
Issue number7
DOIs
StatePublished - Jul 2017
Externally publishedYes

Keywords

  • BMP
  • Myocardial infarction
  • Smad
  • TGF-β

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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