The frequency of histologically confirmed Barrett's esophagus varies by the combination of ethnicity and gender

Sian S. Chisholm, Joe E. Khoury, M. Mazen Jamal, Carlos Palacio, Sunitha Pudhota, Kenneth J Vega

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Barrett's esophagus (BE) is the primary risk factor for esophageal adenocarcinoma (EAC). Limited data exists regarding the frequency of histologically confirmed BE by both gender and ethnicity in the United States. The study aim was to determine whether the frequency of histologically confirmed BE varies by ethnicity and gender. Methods: The University of Florida-Jacksonville endoscopy database was reviewed for all cases of salmon colored esophageal mucosa from September 2002 to August 2007. Histologic BE was diagnosed only if salmon colored esophageal mucosa was seen endoscopically and biopsy confirmed intestinal metaplasia with goblet cells. Data collected included: age at diagnosis, self-reported ethnicity [non-Hispanic white (nHw) or African American (AA)], gender, procedure indication, gastroesophageal reflux disease (GERD) history, atypical manifestations, cigarette smoking, alcohol use, proton pump inhibitor (PPI) use, BE endoscopic length, absence/presence of hiatal hernia, stricture or ulcer, and absence/presence/grade of dysplasia. Results: Salmon colored esophageal mucosa was identified in 391/7,308 patients, distributed ethnically as 306 nHw and 85 AA. Histologic BE was confirmed in 111/391 patients with ethnic distribution of: 95 nHw and 16 AA. Histologically confirmed BE frequency varied both by gender and ethnicity with nHw males having the highest (42.3%) and AA females the lowest (12.3%). Histologically confirmed BE frequency differed significantly between nHw males and nHw/AA females only (P < 0.005). Conclusions: Histologically confirmed BE frequency varies by ethnicity and gender with nHw males having the highest frequency/risk and AA females the lowest. Investigation to improve understanding of the impact of race and gender in BE formation should be performed.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalJournal of Gastrointestinal Oncology
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Barrett Esophagus
African Americans
Salmon
Hiatal Hernia
Goblet Cells
Proton Pump Inhibitors
Metaplasia
Gastroesophageal Reflux
Endoscopy
Ulcer
Pathologic Constriction
Adenocarcinoma
Smoking
Alcohols
Databases
Biopsy

Keywords

  • Barrett's esophagus (BE)
  • Ethnicity
  • Frequency
  • Gender
  • Histology

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

The frequency of histologically confirmed Barrett's esophagus varies by the combination of ethnicity and gender. / Chisholm, Sian S.; Khoury, Joe E.; Jamal, M. Mazen; Palacio, Carlos; Pudhota, Sunitha; Vega, Kenneth J.

In: Journal of Gastrointestinal Oncology, Vol. 8, No. 1, 01.01.2017, p. 102-108.

Research output: Contribution to journalArticle

Chisholm, Sian S. ; Khoury, Joe E. ; Jamal, M. Mazen ; Palacio, Carlos ; Pudhota, Sunitha ; Vega, Kenneth J. / The frequency of histologically confirmed Barrett's esophagus varies by the combination of ethnicity and gender. In: Journal of Gastrointestinal Oncology. 2017 ; Vol. 8, No. 1. pp. 102-108.
@article{5246a1dad01247ecab615f73d80e224e,
title = "The frequency of histologically confirmed Barrett's esophagus varies by the combination of ethnicity and gender",
abstract = "Background: Barrett's esophagus (BE) is the primary risk factor for esophageal adenocarcinoma (EAC). Limited data exists regarding the frequency of histologically confirmed BE by both gender and ethnicity in the United States. The study aim was to determine whether the frequency of histologically confirmed BE varies by ethnicity and gender. Methods: The University of Florida-Jacksonville endoscopy database was reviewed for all cases of salmon colored esophageal mucosa from September 2002 to August 2007. Histologic BE was diagnosed only if salmon colored esophageal mucosa was seen endoscopically and biopsy confirmed intestinal metaplasia with goblet cells. Data collected included: age at diagnosis, self-reported ethnicity [non-Hispanic white (nHw) or African American (AA)], gender, procedure indication, gastroesophageal reflux disease (GERD) history, atypical manifestations, cigarette smoking, alcohol use, proton pump inhibitor (PPI) use, BE endoscopic length, absence/presence of hiatal hernia, stricture or ulcer, and absence/presence/grade of dysplasia. Results: Salmon colored esophageal mucosa was identified in 391/7,308 patients, distributed ethnically as 306 nHw and 85 AA. Histologic BE was confirmed in 111/391 patients with ethnic distribution of: 95 nHw and 16 AA. Histologically confirmed BE frequency varied both by gender and ethnicity with nHw males having the highest (42.3{\%}) and AA females the lowest (12.3{\%}). Histologically confirmed BE frequency differed significantly between nHw males and nHw/AA females only (P < 0.005). Conclusions: Histologically confirmed BE frequency varies by ethnicity and gender with nHw males having the highest frequency/risk and AA females the lowest. Investigation to improve understanding of the impact of race and gender in BE formation should be performed.",
keywords = "Barrett's esophagus (BE), Ethnicity, Frequency, Gender, Histology",
author = "Chisholm, {Sian S.} and Khoury, {Joe E.} and Jamal, {M. Mazen} and Carlos Palacio and Sunitha Pudhota and Vega, {Kenneth J}",
year = "2017",
month = "1",
day = "1",
doi = "10.21037/jgo.2016.12.07",
language = "English (US)",
volume = "8",
pages = "102--108",
journal = "Journal of Gastrointestinal Oncology",
issn = "2078-6891",
publisher = "Pioneer Bioscience Publishing Company (PBPC)",
number = "1",

}

TY - JOUR

T1 - The frequency of histologically confirmed Barrett's esophagus varies by the combination of ethnicity and gender

AU - Chisholm, Sian S.

AU - Khoury, Joe E.

AU - Jamal, M. Mazen

AU - Palacio, Carlos

AU - Pudhota, Sunitha

AU - Vega, Kenneth J

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Barrett's esophagus (BE) is the primary risk factor for esophageal adenocarcinoma (EAC). Limited data exists regarding the frequency of histologically confirmed BE by both gender and ethnicity in the United States. The study aim was to determine whether the frequency of histologically confirmed BE varies by ethnicity and gender. Methods: The University of Florida-Jacksonville endoscopy database was reviewed for all cases of salmon colored esophageal mucosa from September 2002 to August 2007. Histologic BE was diagnosed only if salmon colored esophageal mucosa was seen endoscopically and biopsy confirmed intestinal metaplasia with goblet cells. Data collected included: age at diagnosis, self-reported ethnicity [non-Hispanic white (nHw) or African American (AA)], gender, procedure indication, gastroesophageal reflux disease (GERD) history, atypical manifestations, cigarette smoking, alcohol use, proton pump inhibitor (PPI) use, BE endoscopic length, absence/presence of hiatal hernia, stricture or ulcer, and absence/presence/grade of dysplasia. Results: Salmon colored esophageal mucosa was identified in 391/7,308 patients, distributed ethnically as 306 nHw and 85 AA. Histologic BE was confirmed in 111/391 patients with ethnic distribution of: 95 nHw and 16 AA. Histologically confirmed BE frequency varied both by gender and ethnicity with nHw males having the highest (42.3%) and AA females the lowest (12.3%). Histologically confirmed BE frequency differed significantly between nHw males and nHw/AA females only (P < 0.005). Conclusions: Histologically confirmed BE frequency varies by ethnicity and gender with nHw males having the highest frequency/risk and AA females the lowest. Investigation to improve understanding of the impact of race and gender in BE formation should be performed.

AB - Background: Barrett's esophagus (BE) is the primary risk factor for esophageal adenocarcinoma (EAC). Limited data exists regarding the frequency of histologically confirmed BE by both gender and ethnicity in the United States. The study aim was to determine whether the frequency of histologically confirmed BE varies by ethnicity and gender. Methods: The University of Florida-Jacksonville endoscopy database was reviewed for all cases of salmon colored esophageal mucosa from September 2002 to August 2007. Histologic BE was diagnosed only if salmon colored esophageal mucosa was seen endoscopically and biopsy confirmed intestinal metaplasia with goblet cells. Data collected included: age at diagnosis, self-reported ethnicity [non-Hispanic white (nHw) or African American (AA)], gender, procedure indication, gastroesophageal reflux disease (GERD) history, atypical manifestations, cigarette smoking, alcohol use, proton pump inhibitor (PPI) use, BE endoscopic length, absence/presence of hiatal hernia, stricture or ulcer, and absence/presence/grade of dysplasia. Results: Salmon colored esophageal mucosa was identified in 391/7,308 patients, distributed ethnically as 306 nHw and 85 AA. Histologic BE was confirmed in 111/391 patients with ethnic distribution of: 95 nHw and 16 AA. Histologically confirmed BE frequency varied both by gender and ethnicity with nHw males having the highest (42.3%) and AA females the lowest (12.3%). Histologically confirmed BE frequency differed significantly between nHw males and nHw/AA females only (P < 0.005). Conclusions: Histologically confirmed BE frequency varies by ethnicity and gender with nHw males having the highest frequency/risk and AA females the lowest. Investigation to improve understanding of the impact of race and gender in BE formation should be performed.

KW - Barrett's esophagus (BE)

KW - Ethnicity

KW - Frequency

KW - Gender

KW - Histology

UR - http://www.scopus.com/inward/record.url?scp=85014412384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014412384&partnerID=8YFLogxK

U2 - 10.21037/jgo.2016.12.07

DO - 10.21037/jgo.2016.12.07

M3 - Article

VL - 8

SP - 102

EP - 108

JO - Journal of Gastrointestinal Oncology

JF - Journal of Gastrointestinal Oncology

SN - 2078-6891

IS - 1

ER -