The genetic and environmental factors for keratoconus

Ariela Gordon-Shaag, Michel Millodot, Einat Shneor, Yutao Liu

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its pathogenesis. This review is to summarize the current research development in KC epidemiology and genetic etiology. Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography. Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses. A number of genes have been discovered at a relatively rapid pace. The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies.

Original languageEnglish (US)
Article number795738
JournalBioMed Research International
Volume2015
DOIs
StatePublished - Jan 1 2015

Fingerprint

Keratoconus
Genes
Cornea
Epidemiology
Sun
Geography
Astigmatism
Molecular Epidemiology
Cones
Chromosome Mapping
Genome-Wide Association Study
Myopia
Genetic Association Studies
Solar System
Ethnic Groups
Research
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

The genetic and environmental factors for keratoconus. / Gordon-Shaag, Ariela; Millodot, Michel; Shneor, Einat; Liu, Yutao.

In: BioMed Research International, Vol. 2015, 795738, 01.01.2015.

Research output: Contribution to journalReview article

Gordon-Shaag, Ariela ; Millodot, Michel ; Shneor, Einat ; Liu, Yutao. / The genetic and environmental factors for keratoconus. In: BioMed Research International. 2015 ; Vol. 2015.
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