The importance of tyrosine phosphorylation in angiotensin II signaling

Kenneth E. Bernstein, Mario B Marrero

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Angiotensin II plays a critical role in the regulation of vascular resistance and intravascular volume. Virtually all of the physiologic effects of angiotensin H are mediated by the AT1 receptor, a seven-transmembrane spanning receptor. Although G proteins play an important role in the signaling of this class of receptors, it has become increasingly clear that tyrosine phosphorylation is also intimately involved in AT1 receptor signaling. In response to angiotensin II, both smooth muscle and glomerular mesangial cells tyrosine phosphorylate the γ isoform of phospholipase C. This is critical to downstream signaling events, including the intracellular generation of 1,4,5-inositol triphosphate. The soluble cytoplasmic kinase Src appears to be activated by angiotensin II and to play an important role in the phosphorylation of phospholipase C. Angiotensin II, acting through the AT1 receptor, causes Jak kinase phosphorylation and activation. This, in turn, leads to STAT phosphorylation and translocation to the nucleus. Finally, we present data that indicate that angiotensin II activates Ras and leads to Ras-Raf-1 complex formation. Activation of this pathway also appears to require active Src. These studies provide compelling evidence that tyrosine phosphorylation plays an important role in the signaling of angiotensin II. The exact biochemical mechanism by which a seven- transmembrane receptor stimulates intracellular kinases to be elucidated.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1996

Fingerprint

Angiotensin II
Tyrosine
Phosphorylation
Type C Phospholipases
Phosphotransferases
Inositol 1,4,5-Trisphosphate
Mesangial Cells
src-Family Kinases
Angiotensins
GTP-Binding Proteins
Vascular Resistance
Smooth Muscle
Protein Isoforms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The importance of tyrosine phosphorylation in angiotensin II signaling. / Bernstein, Kenneth E.; Marrero, Mario B.

In: Trends in Cardiovascular Medicine, Vol. 6, No. 6, 01.01.1996, p. 179-187.

Research output: Contribution to journalReview article

Bernstein, Kenneth E. ; Marrero, Mario B. / The importance of tyrosine phosphorylation in angiotensin II signaling. In: Trends in Cardiovascular Medicine. 1996 ; Vol. 6, No. 6. pp. 179-187.
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