The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases

Christine C. Johnson, Dennis R. Ownby

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Among the many areas being revolutionized by the recent introduction of culture-independent microbial identification techniques is investigation of the relationship between close contact with large animals, antibiotics, breast feeding, mode of birth, and other exposures during infancy as related to a reduced risk of asthma and allergic disease. These exposures were originally clustered under the “Hygiene Hypothesis” which has evolved into the “Microbiota Hypothesis”. This review begins by summarizing epidemiologic studies suggesting that the common feature of these allergy risk-related exposures is their influence on the founding and early development of a child's gut microbiota. Next, studies using culture-independent techniques are presented showing that children who have experienced the exposures of interest have altered gut microbiota. Finally, selected mouse and human studies are presented which begin to corroborate the protective exposures identified in epidemiologic studies by elucidating mechanisms through which microbes can alter immune development and function. These microbially driven immune alterations demonstrate that microbial exposures in many cases could alter the risk of subsequent allergic disease and asthma. Hopefully, a better understanding of how microbes influence allergic disease will lead to safe and effective methods for reducing the prevalence of all forms of allergic disease.

Original languageEnglish (US)
Pages (from-to)60-70
Number of pages11
JournalTranslational Research
Volume179
DOIs
StatePublished - Jan 1 2017

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Pediatrics
Asthma
Epidemiologic Studies
Hygiene Hypothesis
Allergies
Culture Techniques
Microbiota
Child Development
Breast Feeding
Hypersensitivity
Animals
Parturition
Anti-Bacterial Agents
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

Cite this

The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases. / Johnson, Christine C.; Ownby, Dennis R.

In: Translational Research, Vol. 179, 01.01.2017, p. 60-70.

Research output: Contribution to journalReview article

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