The insights of Let-7 miRNAs in oncogenesis and stem cell potency

Xin Sun, Jian Liu, Chongwen Xu, Shou-Ching Tang, Hong Ren

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.

Original languageEnglish (US)
Pages (from-to)1779-1788
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume20
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • DNA methylation
  • Let-7 miRNAs
  • anti-cancer research
  • cancer stem cells
  • clinical application
  • non-coding RNAs
  • regulatory loops

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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