The kinetics of estrogen binding to rat α-fetoprotein

Brooks Allen Keel, T. O. Abney

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.

Original languageEnglish (US)
Pages (from-to)503-505
Number of pages3
JournalExperientia
Volume40
Issue number5
DOIs
StatePublished - May 1 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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