The M gamma chain of human fetal hemoglobin.

T. H. Huisman, Ferdane Kutlar, Abdullah Kutlar, J. B. Wilson, H. F. Harris

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A new gamma chain of human fetal hemoglobin, the M gamma chain, has been detected by high performance liquid chromatography (HPLC). It is characterized by a Leu----Met replacement at position gamma 141; no other structural variations have been found. The M gamma chain has been observed in red cell lysates of subjects with a heterozygosity for one of many types of hereditary persistence of fetal hemoglobin (HPFH), in sickle cell anemia, and in a few cord blood samples. At present, the genetic cause of this newly discovered heterogeneity is not known; an infidelity in translation or the existence of an unrecognized gamma globin gene should be considered.

Original languageEnglish (US)
Pages (from-to)507-517
Number of pages11
JournalProgress in Clinical and Biological Research
Volume251
StatePublished - Jan 1 1987

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Fetal Hemoglobin
Hemoglobin M
gamma-Globins
Sickle Cell Anemia
Fetal Blood
High Pressure Liquid Chromatography
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Huisman, T. H., Kutlar, F., Kutlar, A., Wilson, J. B., & Harris, H. F. (1987). The M gamma chain of human fetal hemoglobin. Progress in Clinical and Biological Research, 251, 507-517.

The M gamma chain of human fetal hemoglobin. / Huisman, T. H.; Kutlar, Ferdane; Kutlar, Abdullah; Wilson, J. B.; Harris, H. F.

In: Progress in Clinical and Biological Research, Vol. 251, 01.01.1987, p. 507-517.

Research output: Contribution to journalArticle

Huisman, TH, Kutlar, F, Kutlar, A, Wilson, JB & Harris, HF 1987, 'The M gamma chain of human fetal hemoglobin.', Progress in Clinical and Biological Research, vol. 251, pp. 507-517.
Huisman TH, Kutlar F, Kutlar A, Wilson JB, Harris HF. The M gamma chain of human fetal hemoglobin. Progress in Clinical and Biological Research. 1987 Jan 1;251:507-517.
Huisman, T. H. ; Kutlar, Ferdane ; Kutlar, Abdullah ; Wilson, J. B. ; Harris, H. F. / The M gamma chain of human fetal hemoglobin. In: Progress in Clinical and Biological Research. 1987 ; Vol. 251. pp. 507-517.
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