The metric properties of a novel non-motor symptoms scale for Parkinson's disease

Results from an international pilot study

Kallol Ray Chaudhuri, Pablo Martinez-Martin, Richard G. Brown, Kapil Dev Sethi, Fabrizio Stocchi, Per Odin, William Ondo, Kazuo Abe, Graeme MacPhee, Doug MacMahon, Paolo Barone, Martin Rabey, Alison Forbes, Kieran Breen, Susanne Tluk, Yogini Naidu, Warren Olanow, Adrian J. Williams, Sue Thomas, David Rye & 3 others Yoshio Tsuboi, Annette Hand, Anthony H.V. Schapira

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 ± 11 years, duration of disease 6.4 ± 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 ± 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean α, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire.

Original languageEnglish (US)
Pages (from-to)1901-1911
Number of pages11
JournalMovement Disorders
Volume22
Issue number13
DOIs
StatePublished - Oct 15 2007

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Parkinson Disease
Quality of Life
Cognition
Statistical Factor Analysis
Fatigue
Disease Progression
Japan
Sleep
Therapeutics

Keywords

  • Non-motor
  • PD
  • Quality of life
  • Questionnaire
  • UPDRS

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Chaudhuri, K. R., Martinez-Martin, P., Brown, R. G., Sethi, K. D., Stocchi, F., Odin, P., ... Schapira, A. H. V. (2007). The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study. Movement Disorders, 22(13), 1901-1911. https://doi.org/10.1002/mds.21596

The metric properties of a novel non-motor symptoms scale for Parkinson's disease : Results from an international pilot study. / Chaudhuri, Kallol Ray; Martinez-Martin, Pablo; Brown, Richard G.; Sethi, Kapil Dev; Stocchi, Fabrizio; Odin, Per; Ondo, William; Abe, Kazuo; MacPhee, Graeme; MacMahon, Doug; Barone, Paolo; Rabey, Martin; Forbes, Alison; Breen, Kieran; Tluk, Susanne; Naidu, Yogini; Olanow, Warren; Williams, Adrian J.; Thomas, Sue; Rye, David; Tsuboi, Yoshio; Hand, Annette; Schapira, Anthony H.V.

In: Movement Disorders, Vol. 22, No. 13, 15.10.2007, p. 1901-1911.

Research output: Contribution to journalArticle

Chaudhuri, KR, Martinez-Martin, P, Brown, RG, Sethi, KD, Stocchi, F, Odin, P, Ondo, W, Abe, K, MacPhee, G, MacMahon, D, Barone, P, Rabey, M, Forbes, A, Breen, K, Tluk, S, Naidu, Y, Olanow, W, Williams, AJ, Thomas, S, Rye, D, Tsuboi, Y, Hand, A & Schapira, AHV 2007, 'The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study', Movement Disorders, vol. 22, no. 13, pp. 1901-1911. https://doi.org/10.1002/mds.21596
Chaudhuri, Kallol Ray ; Martinez-Martin, Pablo ; Brown, Richard G. ; Sethi, Kapil Dev ; Stocchi, Fabrizio ; Odin, Per ; Ondo, William ; Abe, Kazuo ; MacPhee, Graeme ; MacMahon, Doug ; Barone, Paolo ; Rabey, Martin ; Forbes, Alison ; Breen, Kieran ; Tluk, Susanne ; Naidu, Yogini ; Olanow, Warren ; Williams, Adrian J. ; Thomas, Sue ; Rye, David ; Tsuboi, Yoshio ; Hand, Annette ; Schapira, Anthony H.V. / The metric properties of a novel non-motor symptoms scale for Parkinson's disease : Results from an international pilot study. In: Movement Disorders. 2007 ; Vol. 22, No. 13. pp. 1901-1911.
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