The mitochondrial Na+/Ca2+ exchanger is necessary but not sufficient for Ca2+ homeostasis and viability

Timon Cheng Yi Liu, Xiao Ming Tang, Rui Duan, Lei Ma, Ling Zhu, Quanguang Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Luongo et al. found that the mitochondrial Na+/Ca2+ exchanger (NCLX) was essential for Ca2+ homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models. Results: The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not.Conclusion: The NCLX may be necessary but is not sufficient for Ca2+ homeostasis and viability.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages281-285
Number of pages5
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1072
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Liu, T. C. Y., Tang, X. M., Duan, R., Ma, L., Zhu, L., & Zhang, Q. (2018). The mitochondrial Na+/Ca2+ exchanger is necessary but not sufficient for Ca2+ homeostasis and viability. In Advances in Experimental Medicine and Biology (pp. 281-285). (Advances in Experimental Medicine and Biology; Vol. 1072). Springer New York LLC. https://doi.org/10.1007/978-3-319-91287-5_45