The mitochondrial Na + /Ca 2+ exchanger is necessary but not sufficient for Ca 2+ homeostasis and viability

Timon Cheng Yi Liu, Xiao Ming Tang, Rui Duan, Lei Ma, Ling Zhu, Quanguang Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Luongo et al. found that the mitochondrial Na + /Ca 2+ exchanger (NCLX) was essential for Ca 2+ homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models. Results: The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not.Conclusion: The NCLX may be necessary but is not sufficient for Ca 2+ homeostasis and viability.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages281-285
Number of pages5
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1072
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Sodium-Calcium Exchanger
Homeostasis
Fractals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Liu, T. C. Y., Tang, X. M., Duan, R., Ma, L., Zhu, L., & Zhang, Q. (2018). The mitochondrial Na + /Ca 2+ exchanger is necessary but not sufficient for Ca 2+ homeostasis and viability In Advances in Experimental Medicine and Biology (pp. 281-285). (Advances in Experimental Medicine and Biology; Vol. 1072). Springer New York LLC. https://doi.org/10.1007/978-3-319-91287-5_45

The mitochondrial Na + /Ca 2+ exchanger is necessary but not sufficient for Ca 2+ homeostasis and viability . / Liu, Timon Cheng Yi; Tang, Xiao Ming; Duan, Rui; Ma, Lei; Zhu, Ling; Zhang, Quanguang.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 281-285 (Advances in Experimental Medicine and Biology; Vol. 1072).

Research output: Chapter in Book/Report/Conference proceedingChapter

Liu, TCY, Tang, XM, Duan, R, Ma, L, Zhu, L & Zhang, Q 2018, The mitochondrial Na + /Ca 2+ exchanger is necessary but not sufficient for Ca 2+ homeostasis and viability in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1072, Springer New York LLC, pp. 281-285. https://doi.org/10.1007/978-3-319-91287-5_45
Liu TCY, Tang XM, Duan R, Ma L, Zhu L, Zhang Q. The mitochondrial Na + /Ca 2+ exchanger is necessary but not sufficient for Ca 2+ homeostasis and viability In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 281-285. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-91287-5_45
Liu, Timon Cheng Yi ; Tang, Xiao Ming ; Duan, Rui ; Ma, Lei ; Zhu, Ling ; Zhang, Quanguang. / The mitochondrial Na + /Ca 2+ exchanger is necessary but not sufficient for Ca 2+ homeostasis and viability Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 281-285 (Advances in Experimental Medicine and Biology).
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AU - Zhu, Ling

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