The p38 and p34 polypeptides of growth cone particle membranes are the α- and β-subunits of G proteins

Brian T. Edmonds, Carolyn R. Moomaw, Joan T. Hsu, Clive A. Slaughter, Leland Ellis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Growth cone particle (GCP) membranes prepared from fetal day 17 rat brain are comprised of 5 major polypeptides as analyzed by SDS-PAGE: tubulin (p52), actin (p42), pp46/GAP-43 and two unidentified species, p38 and p3414,46,52. Antibodies specific for the α- and β-subunits of G proteins recognize p38 and p34, respectively, on immunoblots following one- and two-dimensional electrophoretic separation. That G protein subunits comprise major species of GCP membrane-associated polypeptides suggests a role for G proteins in transmembrane signaling in nerve growth cones.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalDevelopmental Brain Research
Volume56
Issue number1
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

Fingerprint

Growth Cones
GTP-Binding Proteins
Peptides
Membranes
GAP-43 Protein
Extraembryonic Membranes
Protein Subunits
Tubulin
Actins
Polyacrylamide Gel Electrophoresis
Antibodies
Brain

Keywords

  • G protein
  • Growth cone
  • Growth cone particle
  • Growth cone particle membrane

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Cite this

The p38 and p34 polypeptides of growth cone particle membranes are the α- and β-subunits of G proteins. / Edmonds, Brian T.; Moomaw, Carolyn R.; Hsu, Joan T.; Slaughter, Clive A.; Ellis, Leland.

In: Developmental Brain Research, Vol. 56, No. 1, 01.10.1990, p. 131-136.

Research output: Contribution to journalArticle

Edmonds, Brian T. ; Moomaw, Carolyn R. ; Hsu, Joan T. ; Slaughter, Clive A. ; Ellis, Leland. / The p38 and p34 polypeptides of growth cone particle membranes are the α- and β-subunits of G proteins. In: Developmental Brain Research. 1990 ; Vol. 56, No. 1. pp. 131-136.
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