The p38 and p34 polypeptides of growth cone particle membranes are the α- and β-subunits of G proteins

Brian T. Edmonds, Carolyn R. Moomaw, Joan T. Hsu, Clive A. Slaughter, Leland Ellis

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Growth cone particle (GCP) membranes prepared from fetal day 17 rat brain are comprised of 5 major polypeptides as analyzed by SDS-PAGE: tubulin (p52), actin (p42), pp46/GAP-43 and two unidentified species, p38 and p3414,46,52. Antibodies specific for the α- and β-subunits of G proteins recognize p38 and p34, respectively, on immunoblots following one- and two-dimensional electrophoretic separation. That G protein subunits comprise major species of GCP membrane-associated polypeptides suggests a role for G proteins in transmembrane signaling in nerve growth cones.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalDevelopmental Brain Research
Volume56
Issue number1
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

Keywords

  • G protein
  • Growth cone
  • Growth cone particle
  • Growth cone particle membrane

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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