The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy

Charles F. Hildebolt, Thomas K. Pilgram, Naoko Yokoyama-Crothers, Michael W. Vannier, Mary Dotson, Jane Muckerman, Reina Armamento-Villareal, Jay Hauser, Sheldon Cohen, E. Eugenia Kardaris, Philip Jerry Hanes, Michael K. Shrout, Roberto Civitelli

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: The loss of ovarian function at menopause is associated with loss of postcranial and oral bone. Hormone/estrogen replacement therapy (HRT/ERT) has a positive effect on both postcranial and oral bone. The objective of the study was to determine if the positive effect of HRT/ERT on alveolar crest height (ACH) is generalized or site specific. Methods: The sample consisted of 49 women who completed a 3-year, HRT/ERT prospective study. Cemento-enamel junction distances (ACH) were measured on digitized images of bitewing radiographs. Lumbar spine and proximal femur bone mineral densities (BMDs) were determined with dual-energy x-ray absorptiometric scans. Measurements were made at baseline and at the end of year 3. For the 3-year study period, mean change in ACH was determined for each patient. In addition, the sites with the greatest, second and third greatest ACH changes were determined for each patient. Correlations between changes in ACH (as determined by the various methods) and postcranial BMD were determined. Results: Mean ACH changes had an average correlation (r) of -0.24 with femoral and lumbar spine BMDs. Although the largest site-specific change in ACH resulted in a mean correlation of -0.21, the correlations for the second and third largest changes in ACH dropped to -0.15 and -0.12. Overall, the correlations for site-specific changes were substantively smaller than those for generalized change. Conclusions: The data of this study indicate that ACH change attributable to HRT/ERT is generalized rather than site specific. Studies of the effect of HRT/ERT on ACH should employ multiple measurements to minimize measurement errors associated with site-specific measurements.

Original languageEnglish (US)
Pages (from-to)1279-1284
Number of pages6
JournalJournal of periodontology
Volume73
Issue number11
DOIs
StatePublished - Nov 1 2002

Fingerprint

Estrogen Replacement Therapy
Hormone Replacement Therapy
Bone Density
Spine
Bone and Bones
Dental Enamel
Menopause
Thigh
Femur
X-Rays
Prospective Studies

Keywords

  • Alveolar bone loss/therapy
  • Bone regeneration
  • Estrogen replacement therapy
  • Hormone replacement therapy
  • Postmenopausal

ASJC Scopus subject areas

  • Periodontics

Cite this

Hildebolt, C. F., Pilgram, T. K., Yokoyama-Crothers, N., Vannier, M. W., Dotson, M., Muckerman, J., ... Civitelli, R. (2002). The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy. Journal of periodontology, 73(11), 1279-1284. https://doi.org/10.1902/jop.2002.73.11.1279

The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy. / Hildebolt, Charles F.; Pilgram, Thomas K.; Yokoyama-Crothers, Naoko; Vannier, Michael W.; Dotson, Mary; Muckerman, Jane; Armamento-Villareal, Reina; Hauser, Jay; Cohen, Sheldon; Kardaris, E. Eugenia; Hanes, Philip Jerry; Shrout, Michael K.; Civitelli, Roberto.

In: Journal of periodontology, Vol. 73, No. 11, 01.11.2002, p. 1279-1284.

Research output: Contribution to journalArticle

Hildebolt, CF, Pilgram, TK, Yokoyama-Crothers, N, Vannier, MW, Dotson, M, Muckerman, J, Armamento-Villareal, R, Hauser, J, Cohen, S, Kardaris, EE, Hanes, PJ, Shrout, MK & Civitelli, R 2002, 'The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy', Journal of periodontology, vol. 73, no. 11, pp. 1279-1284. https://doi.org/10.1902/jop.2002.73.11.1279
Hildebolt, Charles F. ; Pilgram, Thomas K. ; Yokoyama-Crothers, Naoko ; Vannier, Michael W. ; Dotson, Mary ; Muckerman, Jane ; Armamento-Villareal, Reina ; Hauser, Jay ; Cohen, Sheldon ; Kardaris, E. Eugenia ; Hanes, Philip Jerry ; Shrout, Michael K. ; Civitelli, Roberto. / The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy. In: Journal of periodontology. 2002 ; Vol. 73, No. 11. pp. 1279-1284.
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abstract = "Background: The loss of ovarian function at menopause is associated with loss of postcranial and oral bone. Hormone/estrogen replacement therapy (HRT/ERT) has a positive effect on both postcranial and oral bone. The objective of the study was to determine if the positive effect of HRT/ERT on alveolar crest height (ACH) is generalized or site specific. Methods: The sample consisted of 49 women who completed a 3-year, HRT/ERT prospective study. Cemento-enamel junction distances (ACH) were measured on digitized images of bitewing radiographs. Lumbar spine and proximal femur bone mineral densities (BMDs) were determined with dual-energy x-ray absorptiometric scans. Measurements were made at baseline and at the end of year 3. For the 3-year study period, mean change in ACH was determined for each patient. In addition, the sites with the greatest, second and third greatest ACH changes were determined for each patient. Correlations between changes in ACH (as determined by the various methods) and postcranial BMD were determined. Results: Mean ACH changes had an average correlation (r) of -0.24 with femoral and lumbar spine BMDs. Although the largest site-specific change in ACH resulted in a mean correlation of -0.21, the correlations for the second and third largest changes in ACH dropped to -0.15 and -0.12. Overall, the correlations for site-specific changes were substantively smaller than those for generalized change. Conclusions: The data of this study indicate that ACH change attributable to HRT/ERT is generalized rather than site specific. Studies of the effect of HRT/ERT on ACH should employ multiple measurements to minimize measurement errors associated with site-specific measurements.",
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AU - Pilgram, Thomas K.

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AU - Vannier, Michael W.

AU - Dotson, Mary

AU - Muckerman, Jane

AU - Armamento-Villareal, Reina

AU - Hauser, Jay

AU - Cohen, Sheldon

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N2 - Background: The loss of ovarian function at menopause is associated with loss of postcranial and oral bone. Hormone/estrogen replacement therapy (HRT/ERT) has a positive effect on both postcranial and oral bone. The objective of the study was to determine if the positive effect of HRT/ERT on alveolar crest height (ACH) is generalized or site specific. Methods: The sample consisted of 49 women who completed a 3-year, HRT/ERT prospective study. Cemento-enamel junction distances (ACH) were measured on digitized images of bitewing radiographs. Lumbar spine and proximal femur bone mineral densities (BMDs) were determined with dual-energy x-ray absorptiometric scans. Measurements were made at baseline and at the end of year 3. For the 3-year study period, mean change in ACH was determined for each patient. In addition, the sites with the greatest, second and third greatest ACH changes were determined for each patient. Correlations between changes in ACH (as determined by the various methods) and postcranial BMD were determined. Results: Mean ACH changes had an average correlation (r) of -0.24 with femoral and lumbar spine BMDs. Although the largest site-specific change in ACH resulted in a mean correlation of -0.21, the correlations for the second and third largest changes in ACH dropped to -0.15 and -0.12. Overall, the correlations for site-specific changes were substantively smaller than those for generalized change. Conclusions: The data of this study indicate that ACH change attributable to HRT/ERT is generalized rather than site specific. Studies of the effect of HRT/ERT on ACH should employ multiple measurements to minimize measurement errors associated with site-specific measurements.

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