The prognostic implications of low serum CA 125 levels prior to the second-look operation for stage III and IV epithelial ovarian cancer

H. H. Gallion, J. E. Hunter, J. R. van Nagell, H. E. Averette, J. M. Cain, L. J. Copeland, R. V. Higgins, N. Husseinzadeh, W. A. Nahhas, E. E. Partridge, S. H. Pursell

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Second-look laparotomy is performed to evaluate response to chemotherapy and to determine the need for additional treatment. The relationship between absolute levels of serum CA 125 <35 u/ml and disease status at second-look operation was evaluated in 95 patients with advanced-stage epithelial ovarian cancer. Eighty-six patients had Stage III disease and nine patients had Stage IV cancer. Residual tumor was documented at second-look laparotomy in 52 (55%) of the patients studied. Forty-nine percent of the 82 patients with serum CA 125 values <20 u/ml had residual disease. In contrast, 12 of 13 (92%) patients with serum CA 125 values of 20-35 u/ml had residual tumor at second-look laparotomy. All patients with serous cystadenocarcinomas and serum CA 125 values of 20-35 u/ml had residual tumor, and two-thirds of these cases had grossly visible disease. The positive predictive value of a serum CA 125 level of 20-35 u/ml was 0.92. These data suggest that second-look laparotomy should be deferred in patients with advanced-stage ovarian cancer until serum CA 125 values are less than 20 u/ml.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalGynecologic Oncology
Volume46
Issue number1
DOIs
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Gallion, H. H., Hunter, J. E., van Nagell, J. R., Averette, H. E., Cain, J. M., Copeland, L. J., Higgins, R. V., Husseinzadeh, N., Nahhas, W. A., Partridge, E. E., & Pursell, S. H. (1992). The prognostic implications of low serum CA 125 levels prior to the second-look operation for stage III and IV epithelial ovarian cancer. Gynecologic Oncology, 46(1), 29-32. https://doi.org/10.1016/0090-8258(92)90190-T