The rate of nutrient supply to normal and denervated slow and fast muscle, and its relation to muscle blood flow

Stephen C. Bondy, Janet L. Purdy, James Edwin Carroll, Kenneth K. Kaiser

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Muscle blood flow, glucose uptake, and the ability of muscle to concentrate an inert amino acid have been studied in vivo using a variety of radiosotopes. The rate of blood flow is four times greater in the slow soleus muscle than in the fast gastrocnemius muscle of the rat, but the rate of deoxyglucose uptake is 14 times higher in the slow muscle relative to the fast muscle. Slow muscle is also able to accumulate the inert amino acid, α-aminoiso-butyric acid, more effectively than does fast muscle. A week after denervation, the rate of blood flow through denervated muscles was increased 30- to 40-fold over control values. However, deoxyglucose uptake was not significantly elevated in the gastrocnemius and was reduced to 20% of control levels in the soleus. The ability of the denervated muscles to concentrate α-aminoisobutyric acid was also impaired. These changes could not be accounted for in terms of an altered inulin space. There is no correlation between the rate of muscle blood flow and the ability of muscle to extract blood-borne nutrients. Impaired transport mechanisms precede and may initiate the major morphological changes that follow muscle denervation.

Original languageEnglish (US)
Pages (from-to)678-683
Number of pages6
JournalExperimental Neurology
Volume51
Issue number3
DOIs
StatePublished - Jan 1 1976

Fingerprint

Food
Muscles
Deoxyglucose
Skeletal Muscle
Muscle Denervation
Aminoisobutyric Acids
Amino Acids
Butyric Acid
Inulin
Denervation
Blood Glucose

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

The rate of nutrient supply to normal and denervated slow and fast muscle, and its relation to muscle blood flow. / Bondy, Stephen C.; Purdy, Janet L.; Carroll, James Edwin; Kaiser, Kenneth K.

In: Experimental Neurology, Vol. 51, No. 3, 01.01.1976, p. 678-683.

Research output: Contribution to journalArticle

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