The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

Mohamed F.M. Mitwally, Robert F. Casper, Michael Peter Diamond

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors during ovarian stimulation reduces amount of gonadotropins required for optimum stimulation. The unique approach of reducing hyperestrogenism, as well as lowering amount of gonadotropins without affecting the number of mature ovarian follicles is an exciting strategy that could result in improvement in the treatment outcome by ameliorating the deleterious effects of the ovarian stimulation on follicular development, endometrial receptivity, as well as oocyte and embryo quality.

Original languageEnglish (US)
Article number54
JournalReproductive Biology and Endocrinology
Volume3
DOIs
StatePublished - Oct 4 2005

Fingerprint

Aromatase Inhibitors
Ovulation Induction
Infertility
Gonadotropins
Embryonic Structures
Fertility Agents
Ovarian Follicle
Ovulation
Oocytes
Therapeutics

ASJC Scopus subject areas

  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment. / Mitwally, Mohamed F.M.; Casper, Robert F.; Diamond, Michael Peter.

In: Reproductive Biology and Endocrinology, Vol. 3, 54, 04.10.2005.

Research output: Contribution to journalReview article

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