The role of DNA methylation in the association between childhood adversity and cardiometabolic disease

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5 Citations (Scopus)

Abstract

Growing evidence suggests that adverse environmental stimuli, especially during sensitive periods in early life, may lead to cardiometabolic disease in later life. However, the underlying biological mechanisms remain a mystery. Recent studies inferred that epigenetic modifications are likely involved. We review recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus–pituitary–adrenal axis as well as the immune system.

Original languageEnglish (US)
Pages (from-to)168-174
Number of pages7
JournalInternational Journal of Cardiology
Volume255
DOIs
StatePublished - Mar 15 2018

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DNA Methylation
Epigenomics
Immune System
Genes

Keywords

  • Cardiometabolic disease
  • Childhood adversity
  • DNA methylation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "The role of DNA methylation in the association between childhood adversity and cardiometabolic disease",
abstract = "Growing evidence suggests that adverse environmental stimuli, especially during sensitive periods in early life, may lead to cardiometabolic disease in later life. However, the underlying biological mechanisms remain a mystery. Recent studies inferred that epigenetic modifications are likely involved. We review recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus–pituitary–adrenal axis as well as the immune system.",
keywords = "Cardiometabolic disease, Childhood adversity, DNA methylation",
author = "Guang Hao and Youssef, {Nagy Adel} and Davis, {Catherine Lucy} and Shaoyong Su",
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AU - Hao, Guang

AU - Youssef, Nagy Adel

AU - Davis, Catherine Lucy

AU - Su, Shaoyong

PY - 2018/3/15

Y1 - 2018/3/15

N2 - Growing evidence suggests that adverse environmental stimuli, especially during sensitive periods in early life, may lead to cardiometabolic disease in later life. However, the underlying biological mechanisms remain a mystery. Recent studies inferred that epigenetic modifications are likely involved. We review recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus–pituitary–adrenal axis as well as the immune system.

AB - Growing evidence suggests that adverse environmental stimuli, especially during sensitive periods in early life, may lead to cardiometabolic disease in later life. However, the underlying biological mechanisms remain a mystery. Recent studies inferred that epigenetic modifications are likely involved. We review recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus–pituitary–adrenal axis as well as the immune system.

KW - Cardiometabolic disease

KW - Childhood adversity

KW - DNA methylation

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