The role of epigenetics in depression and suicide: A platform for gene-environment interactions

Laura E. Lockwood, Shaoyong Su, Nagy Adel Youssef

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Epigenetics involves functional modifications of genes. The aim of this paper is to explore if an association exists between epigenetics and depression and/or suicide. MedLine/PubMed searches were performed using both Medical Subject Heading (MeSH) and Non-MeSH terms. Based on pre-specified terms and inclusion criteria, sixteen studies met inclusion criteria by the 3 independent reviewers. Epigenetic changes seem to be important in both depression and suicide. All of the studies reviewed herein found significant epigenetic changes associated with depression and suicide except for two. Several studies showed that hypermethylation of BDNF is involved in suicide. TrkB hypermethylation was also shown to be associated with suicide by several studies, specifically in Brodmann's Areas (BA) 8 and 9. Future research is needed in a larger sample to further characterize these changes.

Original languageEnglish (US)
Pages (from-to)235-242
Number of pages8
JournalPsychiatry Research
Volume228
Issue number3
DOIs
StatePublished - Aug 30 2015

Fingerprint

Gene-Environment Interaction
Epigenomics
Suicide
Depression
Medical Subject Headings
Brain-Derived Neurotrophic Factor
PubMed
Genes

Keywords

  • Depression
  • Epigenetics
  • Gene-environment interactions
  • Genes
  • Methylation of genes
  • Suicidality
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

The role of epigenetics in depression and suicide : A platform for gene-environment interactions. / Lockwood, Laura E.; Su, Shaoyong; Youssef, Nagy Adel.

In: Psychiatry Research, Vol. 228, No. 3, 30.08.2015, p. 235-242.

Research output: Contribution to journalReview article

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