The role of glutamate and nitric oxide in the reproductive neuroendocrine system

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Abstract

The preovulatory surge of gonadotropin releasing hormone (GnRH) is essential for mammalian reproduction. Recent work has implicated the neurotransmitters glutamate and nitric oxide as having a key role in this process. Large concentrations of glutamate are found in several hypothalamic nuclei known to be important for GnRH release and glutamate receptors are also located in these key hypothalamic nuclei. Administration of glutamate agonists stimulate GnRH and LH release, while glutamate receptor antagonists attenuate the steroid-induced and preovulatory LH surge. Glutamate has also been implicated in the critical processes of puberty, hormone pulsatility, and sexual behavior. Glutamate is believed to elicit many of these effects by activating the release of the gaseous neurotransmitter, nitric oxide (NO). NO potently stimulates GnRH by activating a heme containing enzyme, guanylate cyclase, which in turn leads to increased production of cGMP and GnRH release. Recent work has focused on identifying anchoring and (or) clustering proteins that target glutamate receptors to the synapse and couple the glutamate-NO neurotransmission system. The present review will discuss these new findings, as well as the role of glutamate and nitric oxide in important mammalian reproductive events, with a focus on the hypothalamic control of preovulatory GnRH release.

Original languageEnglish (US)
Pages (from-to)165-179
Number of pages15
JournalBiochemistry and Cell Biology
Volume78
Issue number3
DOIs
StatePublished - Jan 1 2000

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Neurosecretory Systems
Gonadotropin-Releasing Hormone
Glutamic Acid
Nitric Oxide
Glutamate Receptors
Neurotransmitter Agents
LHRH Receptors
Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
Guanylate Cyclase
Puberty
Heme
Synaptic Transmission
Sexual Behavior
Synapses
Reproduction
Cluster Analysis
Steroids
Hormones
Enzymes

Keywords

  • Glutamate
  • GnRH
  • Hypothalamus
  • Nitric oxide
  • Postsynaptic density

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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