The role of radiation therapy and chemotherapy in the management of airway tumors other than small-cell carcinoma and non-small-cell carcinoma

Joseph Michael Kaminski, Corey J. Langer, Benjamin Movsas

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

In rare pulmonary tumors, the choice of local and systemic therapy is frequently dictated by the histologic cell type and (generally) by extrapolation from the existing therapeutic literature for that cell type's more common presentation; however, this approach might change. We are in the midst of a new biological and technological era in how approach and treat cancer. In a phase I trial for non-small-cell lung cancer, Hayman et al safely treated with radiation doses as high as 102.9 Gy (to limited volumes) using three-dimensional, conformal radiation [100]. Such techniques facilitate radiation dose escalation for thoracic neoplasms while minimizing normal tissue toxicity, potentially enhancing the therapeutic ratio. Furthermore, the entire human genome has been sequenced recently, and scientists are now in the process of discovering the functions of previously unknown sequences and their protein products. DNA microarrays can be used to analyze small tissue samples for the presence of gene variations or mutations (genotyping), performing the equivalent of several thousand "Southern blot" experiments in only a few days. In the future, patients might receive individually tailored therapy based upon unique molecular-genetic alterations of the tumor.

Original languageEnglish (US)
Pages (from-to)149-167
Number of pages19
JournalChest Surgery Clinics of North America
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2003

Fingerprint

Airway Management
Small Cell Carcinoma
Radiotherapy
Carcinoma
Drug Therapy
Radiation
Thoracic Neoplasms
Neoplasms
Human Genome
Therapeutics
Southern Blotting
Oligonucleotide Array Sequence Analysis
Non-Small Cell Lung Carcinoma
Molecular Biology
Lung
Mutation
Genes
Proteins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The role of radiation therapy and chemotherapy in the management of airway tumors other than small-cell carcinoma and non-small-cell carcinoma. / Kaminski, Joseph Michael; Langer, Corey J.; Movsas, Benjamin.

In: Chest Surgery Clinics of North America, Vol. 13, No. 1, 01.02.2003, p. 149-167.

Research output: Contribution to journalReview article

@article{2f73b0909f0942c5a711525a53f95082,
title = "The role of radiation therapy and chemotherapy in the management of airway tumors other than small-cell carcinoma and non-small-cell carcinoma",
abstract = "In rare pulmonary tumors, the choice of local and systemic therapy is frequently dictated by the histologic cell type and (generally) by extrapolation from the existing therapeutic literature for that cell type's more common presentation; however, this approach might change. We are in the midst of a new biological and technological era in how approach and treat cancer. In a phase I trial for non-small-cell lung cancer, Hayman et al safely treated with radiation doses as high as 102.9 Gy (to limited volumes) using three-dimensional, conformal radiation [100]. Such techniques facilitate radiation dose escalation for thoracic neoplasms while minimizing normal tissue toxicity, potentially enhancing the therapeutic ratio. Furthermore, the entire human genome has been sequenced recently, and scientists are now in the process of discovering the functions of previously unknown sequences and their protein products. DNA microarrays can be used to analyze small tissue samples for the presence of gene variations or mutations (genotyping), performing the equivalent of several thousand {"}Southern blot{"} experiments in only a few days. In the future, patients might receive individually tailored therapy based upon unique molecular-genetic alterations of the tumor.",
author = "Kaminski, {Joseph Michael} and Langer, {Corey J.} and Benjamin Movsas",
year = "2003",
month = "2",
day = "1",
doi = "10.1016/S1052-3359(02)00040-6",
language = "English (US)",
volume = "13",
pages = "149--167",
journal = "Thoracic Surgery Clinics",
issn = "1547-4127",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - The role of radiation therapy and chemotherapy in the management of airway tumors other than small-cell carcinoma and non-small-cell carcinoma

AU - Kaminski, Joseph Michael

AU - Langer, Corey J.

AU - Movsas, Benjamin

PY - 2003/2/1

Y1 - 2003/2/1

N2 - In rare pulmonary tumors, the choice of local and systemic therapy is frequently dictated by the histologic cell type and (generally) by extrapolation from the existing therapeutic literature for that cell type's more common presentation; however, this approach might change. We are in the midst of a new biological and technological era in how approach and treat cancer. In a phase I trial for non-small-cell lung cancer, Hayman et al safely treated with radiation doses as high as 102.9 Gy (to limited volumes) using three-dimensional, conformal radiation [100]. Such techniques facilitate radiation dose escalation for thoracic neoplasms while minimizing normal tissue toxicity, potentially enhancing the therapeutic ratio. Furthermore, the entire human genome has been sequenced recently, and scientists are now in the process of discovering the functions of previously unknown sequences and their protein products. DNA microarrays can be used to analyze small tissue samples for the presence of gene variations or mutations (genotyping), performing the equivalent of several thousand "Southern blot" experiments in only a few days. In the future, patients might receive individually tailored therapy based upon unique molecular-genetic alterations of the tumor.

AB - In rare pulmonary tumors, the choice of local and systemic therapy is frequently dictated by the histologic cell type and (generally) by extrapolation from the existing therapeutic literature for that cell type's more common presentation; however, this approach might change. We are in the midst of a new biological and technological era in how approach and treat cancer. In a phase I trial for non-small-cell lung cancer, Hayman et al safely treated with radiation doses as high as 102.9 Gy (to limited volumes) using three-dimensional, conformal radiation [100]. Such techniques facilitate radiation dose escalation for thoracic neoplasms while minimizing normal tissue toxicity, potentially enhancing the therapeutic ratio. Furthermore, the entire human genome has been sequenced recently, and scientists are now in the process of discovering the functions of previously unknown sequences and their protein products. DNA microarrays can be used to analyze small tissue samples for the presence of gene variations or mutations (genotyping), performing the equivalent of several thousand "Southern blot" experiments in only a few days. In the future, patients might receive individually tailored therapy based upon unique molecular-genetic alterations of the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0037302658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037302658&partnerID=8YFLogxK

U2 - 10.1016/S1052-3359(02)00040-6

DO - 10.1016/S1052-3359(02)00040-6

M3 - Review article

VL - 13

SP - 149

EP - 167

JO - Thoracic Surgery Clinics

JF - Thoracic Surgery Clinics

SN - 1547-4127

IS - 1

ER -