The role of redox balance

Stephen J. Ives, Ryan A. Harris, Melissa A.H. Witman, Anette S. Fjeldstad, Ryan S. Garten, John Mcdaniel, D. Walter Wray, Russell S. Richardson

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6%; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7%; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population's greater risk and incidence of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalHypertension
Volume63
Issue number3
DOIs
StatePublished - Mar 1 2014

Fingerprint

Oxidation-Reduction
Antioxidants
Chronic Obstructive Pulmonary Disease
Blood Vessels
Placebos
Pulse Wave Analysis
Ascorbic Acid
Dilatation
Cardiovascular Diseases
Thioctic Acid
Doppler Ultrasonography
Brachial Artery
Incidence
Vitamin E
Cross-Over Studies
Superoxide Dismutase
Free Radicals
Pneumonia
Oxidative Stress
Acids

Keywords

  • free radicals
  • oxidative stress
  • pulmonary disease, chronic obstructive
  • vascular stiffness

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ives, S. J., Harris, R. A., Witman, M. A. H., Fjeldstad, A. S., Garten, R. S., Mcdaniel, J., ... Richardson, R. S. (2014). The role of redox balance. Hypertension, 63(3), 459-467. https://doi.org/10.1161/HYPERTENSIONAHA.113.02255

The role of redox balance. / Ives, Stephen J.; Harris, Ryan A.; Witman, Melissa A.H.; Fjeldstad, Anette S.; Garten, Ryan S.; Mcdaniel, John; Wray, D. Walter; Richardson, Russell S.

In: Hypertension, Vol. 63, No. 3, 01.03.2014, p. 459-467.

Research output: Contribution to journalArticle

Ives, SJ, Harris, RA, Witman, MAH, Fjeldstad, AS, Garten, RS, Mcdaniel, J, Wray, DW & Richardson, RS 2014, 'The role of redox balance', Hypertension, vol. 63, no. 3, pp. 459-467. https://doi.org/10.1161/HYPERTENSIONAHA.113.02255
Ives SJ, Harris RA, Witman MAH, Fjeldstad AS, Garten RS, Mcdaniel J et al. The role of redox balance. Hypertension. 2014 Mar 1;63(3):459-467. https://doi.org/10.1161/HYPERTENSIONAHA.113.02255
Ives, Stephen J. ; Harris, Ryan A. ; Witman, Melissa A.H. ; Fjeldstad, Anette S. ; Garten, Ryan S. ; Mcdaniel, John ; Wray, D. Walter ; Richardson, Russell S. / The role of redox balance. In: Hypertension. 2014 ; Vol. 63, No. 3. pp. 459-467.
@article{8ae3fcd343a840f9b4a26810ed1d747d,
title = "The role of redox balance",
abstract = "Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6{\%}; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7{\%}; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population's greater risk and incidence of cardiovascular disease.",
keywords = "free radicals, oxidative stress, pulmonary disease, chronic obstructive, vascular stiffness",
author = "Ives, {Stephen J.} and Harris, {Ryan A.} and Witman, {Melissa A.H.} and Fjeldstad, {Anette S.} and Garten, {Ryan S.} and John Mcdaniel and Wray, {D. Walter} and Richardson, {Russell S.}",
year = "2014",
month = "3",
day = "1",
doi = "10.1161/HYPERTENSIONAHA.113.02255",
language = "English (US)",
volume = "63",
pages = "459--467",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The role of redox balance

AU - Ives, Stephen J.

AU - Harris, Ryan A.

AU - Witman, Melissa A.H.

AU - Fjeldstad, Anette S.

AU - Garten, Ryan S.

AU - Mcdaniel, John

AU - Wray, D. Walter

AU - Richardson, Russell S.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6%; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7%; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population's greater risk and incidence of cardiovascular disease.

AB - Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function, inflammation, free radical production, vascular dysfunction, and subsequently a greater incidence of cardiovascular disease. By administering an acute oral antioxidant cocktail to patients with COPD (n=30) and controls (n=30), we sought to determine the role of redox balance in the vascular dysfunction of these patients. Using a double-blind, randomized, placebo-controlled, crossover design, patients with COPD and controls were ingested placebo or the antioxidant cocktail (vitamin C, vitamin E, α-lipoic acid) after which brachial artery flow-mediated dilation and carotid-radial pulse wave velocity were assessed using ultrasound Doppler. The patients exhibited lower baseline antioxidant levels (vitamin C and superoxide dismutase activity) and higher levels of oxidative stress (thiobarbituic acid reactive species) in comparison with controls. The patients also displayed lower basal flow-mediated dilation (P<0.05), which was significantly improved with antioxidant cocktail (3.1±0.5 versus 4.7±0.6%; P<0.05; placebo versus antioxidant cocktail), but not controls (6.7±0.6 versus 6.9±0.7%; P>0.05; placebo versus antioxidant cocktail). The antioxidant cocktail also improved pulse wave velocity in patients with COPD (14±1 versus 11±1 m·s; P<0.05; placebo versus antioxidant cocktail) while not affecting controls (11±2 versus 10±1 m·s; P>0.05; placebo versus antioxidant). Patients with COPD exhibit vascular dysfunction, likely mediated by an altered redox balance, which can be acutely mitigated by an oral antioxidant. Therefore, free radically mediated vascular dysfunction may be an important mechanism contributing to this population's greater risk and incidence of cardiovascular disease.

KW - free radicals

KW - oxidative stress

KW - pulmonary disease, chronic obstructive

KW - vascular stiffness

UR - http://www.scopus.com/inward/record.url?scp=84894490710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894490710&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.113.02255

DO - 10.1161/HYPERTENSIONAHA.113.02255

M3 - Article

C2 - 24324045

AN - SCOPUS:84894490710

VL - 63

SP - 459

EP - 467

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3

ER -