The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients

Keith G. LeBlanc, Matthew P. Hughes, Daniel J. Sheehan

Research output: Contribution to journalReview article

16 Scopus citations


Skin cancers are common in organ transplant recipients (OTRs). In this review, we discuss the epidemiology of and risk factors for cutaneous neoplasms, particularly squamous cell carcinoma (SCC) in OTRs. The pathogenesis of SCC is reviewed, as well as the potential mechanisms for tumor progression and metastasis associated with two commonly used immunosuppressive medications: tacrolimus and cyclosporine. Finally, we discuss the mechanism of action and potential preventative use of sirolimus, a member of a newer class of immunosuppressants, the mammalian target of rapamycin inhibitors.

Original languageEnglish (US)
Pages (from-to)744-749
Number of pages6
JournalDermatologic Surgery
Issue number6
StatePublished - Jun 2011


ASJC Scopus subject areas

  • Surgery
  • Dermatology

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