The Role of the Tumor Microenvironment in the Progression of Pancreatic Cancer

Buckminster Farrow, Daniel Albo, David H. Berger

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

Pancreatic cancer is the most lethal abdominal malignancy due to its aggressive growth and rapid development of distant metastases, thus making treatment extremely difficult. Additionally, pancreatic adenocarcinoma is locally invasive, surrounded by a dense desmoplastic reaction which can involve adjacent vital structures, limiting the number of patients who are candidates for surgical resection at the time of diagnosis. Recently the tumor microenvironment in other adenocarcinomas has been determined to be an important mediator of cancer cell behavior; however, few studies have elucidated the tumor-stroma interactions in pancreatic cancer. This review summarizes the role of pancreatic stellate cells, perineural invasion, angiogenesis, and inflammatory cells in fostering pancreatic cancer cell growth and invasion. The importance of extracellular matrix proteins, growth factors, and cytokines is also presented. Finally we suggest ideas for new avenues of research into the pancreatic tumor microenvironment which may permit the development of novel, more effective treatments for pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalJournal of Surgical Research
Volume149
Issue number2
DOIs
StatePublished - Oct 1 2008

Fingerprint

Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma
Pancreatic Stellate Cells
Neoplasms
Foster Home Care
Extracellular Matrix Proteins
Growth and Development
Intercellular Signaling Peptides and Proteins
Cytokines
Neoplasm Metastasis
Therapeutics
Growth
Research

Keywords

  • pancreatic cancer
  • pancreatic stellate cells
  • perineural invasion
  • review
  • tumor microenvironment
  • tumor stroma

ASJC Scopus subject areas

  • Surgery

Cite this

The Role of the Tumor Microenvironment in the Progression of Pancreatic Cancer. / Farrow, Buckminster; Albo, Daniel; Berger, David H.

In: Journal of Surgical Research, Vol. 149, No. 2, 01.10.2008, p. 319-328.

Research output: Contribution to journalReview article

Farrow, Buckminster ; Albo, Daniel ; Berger, David H. / The Role of the Tumor Microenvironment in the Progression of Pancreatic Cancer. In: Journal of Surgical Research. 2008 ; Vol. 149, No. 2. pp. 319-328.
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