The role of vasopressin and atrial natriuretic factor in postoperative fluid retention after the Fontan procedure

J. M. Stewart, M. H. Gewitz, B. J. Clark, K. P. Seligman, A. Romano, G. A. Zeballos, A. Chang, K. Murdison, P. K. Woolf, W. I. Norwood

Research output: Contribution to journalArticle

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Abstract

The Fontan procedure results in right atrial distention and is complicated by fluid retention. Since systemic fluid balance may be hormonally mediated in part and related to right atrium size, we measured plasma atrial natriuretic factor and plasma arginine vasopressin levels in 19 patients undergoing the Fontan procedure and in 12 control patients undergoing other types of heart operations. Preoperative plasma atrial natriuretic factor levels were higher in patients undergoing the Fontan procedure than in control patients (95 ± 16 pg/ml preoperatively versus 50 ± 8 pg/ml; p < 0.05) and increased in patients undergoing the Fontan procedure to 330 ± 48 pg/ml by postoperative day 2 (p < 0.05) but not in control patients. Increased plasma atrial natriuretic factor levels could enhance capillary transudation, but elevated plasma atrial natriuretic factor levels should also enhance diuresis and prevent fluid retention. Vasopressin levels, however, were also increased in patients undergoing the Fontan procedure (from 9 ± 2 pg/ml preoperatively to 144 ± 37 pg/ml at end of operation) and were higher and remained elevated longer than in control patients undergoing heart operations (37 ± 7, 20 ± 4, 16 ± 6 pg/ml on postoperative days 1, 2, and 3 to 10 for the Fontan group compared with 15 ± 4, 4 ± 1, 4 ± 2 pg/ml for control patients). Vasopressin levels were highest in the Fontan group with the most severe fluid retention and effusions (for example, 51 ± 10 pg/ml versus 23 ± 4 pg/ml, on postoperative day 1). Increased vasopressin and atrial natriuretic factor could act synergistically to result in the development of effusions after the Fontan procedure when atrial natriuretic factor-induced capillary transudation is combined with vasopressin-induced antidiuresis.

Original languageEnglish (US)
Pages (from-to)821-829
Number of pages9
JournalJournal of Thoracic and Cardiovascular Surgery
Volume102
Issue number6
StatePublished - Dec 1 1991
Externally publishedYes

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Fontan Procedure
Atrial Natriuretic Factor
Vasopressins
Water-Electrolyte Balance
Arginine Vasopressin
Diuresis
Heart Atria

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Stewart, J. M., Gewitz, M. H., Clark, B. J., Seligman, K. P., Romano, A., Zeballos, G. A., ... Norwood, W. I. (1991). The role of vasopressin and atrial natriuretic factor in postoperative fluid retention after the Fontan procedure. Journal of Thoracic and Cardiovascular Surgery, 102(6), 821-829.

The role of vasopressin and atrial natriuretic factor in postoperative fluid retention after the Fontan procedure. / Stewart, J. M.; Gewitz, M. H.; Clark, B. J.; Seligman, K. P.; Romano, A.; Zeballos, G. A.; Chang, A.; Murdison, K.; Woolf, P. K.; Norwood, W. I.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 102, No. 6, 01.12.1991, p. 821-829.

Research output: Contribution to journalArticle

Stewart, JM, Gewitz, MH, Clark, BJ, Seligman, KP, Romano, A, Zeballos, GA, Chang, A, Murdison, K, Woolf, PK & Norwood, WI 1991, 'The role of vasopressin and atrial natriuretic factor in postoperative fluid retention after the Fontan procedure', Journal of Thoracic and Cardiovascular Surgery, vol. 102, no. 6, pp. 821-829.
Stewart, J. M. ; Gewitz, M. H. ; Clark, B. J. ; Seligman, K. P. ; Romano, A. ; Zeballos, G. A. ; Chang, A. ; Murdison, K. ; Woolf, P. K. ; Norwood, W. I. / The role of vasopressin and atrial natriuretic factor in postoperative fluid retention after the Fontan procedure. In: Journal of Thoracic and Cardiovascular Surgery. 1991 ; Vol. 102, No. 6. pp. 821-829.
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abstract = "The Fontan procedure results in right atrial distention and is complicated by fluid retention. Since systemic fluid balance may be hormonally mediated in part and related to right atrium size, we measured plasma atrial natriuretic factor and plasma arginine vasopressin levels in 19 patients undergoing the Fontan procedure and in 12 control patients undergoing other types of heart operations. Preoperative plasma atrial natriuretic factor levels were higher in patients undergoing the Fontan procedure than in control patients (95 ± 16 pg/ml preoperatively versus 50 ± 8 pg/ml; p < 0.05) and increased in patients undergoing the Fontan procedure to 330 ± 48 pg/ml by postoperative day 2 (p < 0.05) but not in control patients. Increased plasma atrial natriuretic factor levels could enhance capillary transudation, but elevated plasma atrial natriuretic factor levels should also enhance diuresis and prevent fluid retention. Vasopressin levels, however, were also increased in patients undergoing the Fontan procedure (from 9 ± 2 pg/ml preoperatively to 144 ± 37 pg/ml at end of operation) and were higher and remained elevated longer than in control patients undergoing heart operations (37 ± 7, 20 ± 4, 16 ± 6 pg/ml on postoperative days 1, 2, and 3 to 10 for the Fontan group compared with 15 ± 4, 4 ± 1, 4 ± 2 pg/ml for control patients). Vasopressin levels were highest in the Fontan group with the most severe fluid retention and effusions (for example, 51 ± 10 pg/ml versus 23 ± 4 pg/ml, on postoperative day 1). Increased vasopressin and atrial natriuretic factor could act synergistically to result in the development of effusions after the Fontan procedure when atrial natriuretic factor-induced capillary transudation is combined with vasopressin-induced antidiuresis.",
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